Role of cytokines in atypical depression

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Atypical depression (AD) is considered a biologically and psychologically distinct subtype of depression. AD, contrary to melancholic depression (MD), may have different alteration in cytokine activity. Aims: We aimed to investigate the differences of cytokine activity between AD patients and MD patients. Among psychiatric patients visited to the Psychiatry Department, Korea University Medical Center, 105 patients with major depression who met the Diagnostic and Statistical Manual (DSM-IV) criteria based on clinical interviews using a Structured Clinical Interview for DSM-IV were recruited. Among 105 patients, 35 patients had atypical feature. We measured in vitro cytokines (interleukins) IL-2, IL-4, IL-6 and tumor necrosis factor-α (TNF-α). Results: Decreased IL-4 and increased IL-2 was observed in AD patients. IL-6 and TNF-α level of AD patients showed no difference from the controls. Conclusions: Contrary to MD, AD has reversed vegetative symptoms, i.e. hypersomnia and hyperphagia. It is assumed that the phenotype difference between AD and MD might be related to Th1 cytokines (IL-2) and Th2 cytokines (IL-4) and not related to monocytic cytokines (IL-6, and TNF-α).

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNordic Journal of Psychiatry
Volume66
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Depression
Cytokines
Interleukin-2
Interleukin-4
Interleukin-6
Tumor Necrosis Factor-alpha
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Interviews
Disorders of Excessive Somnolence
Hyperphagia
Korea
Phenotype

Keywords

  • Atypical feature
  • Cytokine
  • Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Role of cytokines in atypical depression. / Yoon, Ho-Kyoung; Kim, Yong Ku; Lee, Heon-Jeong; Kwon, Do-Young; Kim, Leen.

In: Nordic Journal of Psychiatry, Vol. 66, No. 3, 01.06.2012, p. 183-188.

Research output: Contribution to journalArticle

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