Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss

Mi Hyun Choi, Ji Eun Na, Ye Ran Yoon, Hyo Jin Lee, Sehyoun Yoon, Im Joo Rhyu, Ja-Hyun Baik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Dopaminergic systems play a major role in reward-related behavior and dysregulation of dopamine (DA) systems can cause several mental disorders, including depression. We previously reported that dopamine D2 receptor knockout (D2R-/-) mice display increased anxiety and depression-like behaviors upon chronic stress. Here, we observed that chronic stress caused myelin loss in wild-type (WT) mice, while the myelin level in D2R-/- mice, which was already lower than that in WT mice, was not affected upon stress. Fewer mature oligodendrocytes (OLs) were observed in the corpus callosum of stressed WT mice, while in D2R-/- mice, both the control and stressed group displayed a decrease in the number of mature OLs. We observed a decrease in the number of active β-catenin (ABC)-expressing and TCF4-expressing cells among OL lineage cells in the corpus callosum of stressed WT mice, while such regulation was not found in D2R-/- mice. Administration of lithium normalized the behavioral impairments and myelin damage induced by chronic stress in WT mice, and restored the number of ABC-positive and TCF4-positive OLs, while such effect was not found in D2R-/- mice. Together, our findings indicate that chronic stress induces myelin loss through the Wnt/β-catenin signaling pathway in association with DA signaling through D2R.

Original languageEnglish
Article number11654
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Dopamine D2 Receptors
Myelin Sheath
Knockout Mice
Oligodendroglia
Catenins
Corpus Callosum
Dopamine
Depression
Wnt Signaling Pathway
Reward
Lithium
Mental Disorders
Anxiety
Control Groups

ASJC Scopus subject areas

  • General

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Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss. / Choi, Mi Hyun; Na, Ji Eun; Yoon, Ye Ran; Lee, Hyo Jin; Yoon, Sehyoun; Rhyu, Im Joo; Baik, Ja-Hyun.

In: Scientific Reports, Vol. 7, No. 1, 11654, 01.12.2017.

Research output: Contribution to journalArticle

Choi, Mi Hyun ; Na, Ji Eun ; Yoon, Ye Ran ; Lee, Hyo Jin ; Yoon, Sehyoun ; Rhyu, Im Joo ; Baik, Ja-Hyun. / Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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