Role of interleukin 28b-related gene polymorphisms in chronic hepatitis c and the response to antiviral therapy in koreans

Young Kul Jung, Ji Hoon Kim, Sung Min Ahn, Jae Won Yang, Sang Jin Park, Jong Woo Kim, Jong Eun Yeon, Oh Sang Kwon, Yun Soo Kim, Duck Joo Choi, Ju Hyun Kim, Kwan Soo Byun

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

BACKGROUND:: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. METHODS:: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. RESULTS:: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ =0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. CONCLUSIONS:: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.

Original languageEnglish
Pages (from-to)644-650
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume47
Issue number7
DOIs
Publication statusPublished - 2013 Aug 1

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Interleukins
Chronic Hepatitis
Antiviral Agents
Genotype
Genes
Chronic Hepatitis C
Therapeutics
Hepacivirus
Ribavirin
Linkage Disequilibrium
Genetic Polymorphisms
Korea
African Americans

Keywords

  • antiviral therapy
  • gene polymorphism
  • hepatitis C virus
  • IL28B
  • Korean

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Role of interleukin 28b-related gene polymorphisms in chronic hepatitis c and the response to antiviral therapy in koreans. / Jung, Young Kul; Kim, Ji Hoon; Ahn, Sung Min; Yang, Jae Won; Park, Sang Jin; Kim, Jong Woo; Yeon, Jong Eun; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun; Byun, Kwan Soo.

In: Journal of Clinical Gastroenterology, Vol. 47, No. 7, 01.08.2013, p. 644-650.

Research output: Contribution to journalReview article

Jung, Young Kul ; Kim, Ji Hoon ; Ahn, Sung Min ; Yang, Jae Won ; Park, Sang Jin ; Kim, Jong Woo ; Yeon, Jong Eun ; Kwon, Oh Sang ; Kim, Yun Soo ; Choi, Duck Joo ; Kim, Ju Hyun ; Byun, Kwan Soo. / Role of interleukin 28b-related gene polymorphisms in chronic hepatitis c and the response to antiviral therapy in koreans. In: Journal of Clinical Gastroenterology. 2013 ; Vol. 47, No. 7. pp. 644-650.
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title = "Role of interleukin 28b-related gene polymorphisms in chronic hepatitis c and the response to antiviral therapy in koreans",
abstract = "BACKGROUND:: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. METHODS:: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. RESULTS:: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5{\%}, the CT-genotype was 11.5{\%}, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5{\%}, the TG-genotype was 10.5{\%}, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ =0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2{\%} (n=58) for 1b, 91.6{\%} (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9{\%} and that in CT-genotype was 40.0{\%}. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. CONCLUSIONS:: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.",
keywords = "antiviral therapy, gene polymorphism, hepatitis C virus, IL28B, Korean",
author = "Jung, {Young Kul} and Kim, {Ji Hoon} and Ahn, {Sung Min} and Yang, {Jae Won} and Park, {Sang Jin} and Kim, {Jong Woo} and Yeon, {Jong Eun} and Kwon, {Oh Sang} and Kim, {Yun Soo} and Choi, {Duck Joo} and Kim, {Ju Hyun} and Byun, {Kwan Soo}",
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T1 - Role of interleukin 28b-related gene polymorphisms in chronic hepatitis c and the response to antiviral therapy in koreans

AU - Jung, Young Kul

AU - Kim, Ji Hoon

AU - Ahn, Sung Min

AU - Yang, Jae Won

AU - Park, Sang Jin

AU - Kim, Jong Woo

AU - Yeon, Jong Eun

AU - Kwon, Oh Sang

AU - Kim, Yun Soo

AU - Choi, Duck Joo

AU - Kim, Ju Hyun

AU - Byun, Kwan Soo

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND:: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. METHODS:: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. RESULTS:: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ =0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. CONCLUSIONS:: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.

AB - BACKGROUND:: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. METHODS:: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. RESULTS:: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ =0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. CONCLUSIONS:: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B.

KW - antiviral therapy

KW - gene polymorphism

KW - hepatitis C virus

KW - IL28B

KW - Korean

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DO - 10.1097/MCG.0b013e3182896abf

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JO - Journal of Clinical Gastroenterology

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