Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation

Sun Young Kwon, Jae-Hong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B4 receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells. We observed that highly elevated expression levels of BLT2 are critical for the pathogenesis leading to allergic airway inflammation, and that if BLT2 expression is downregulated by siBLT2-mediated knockdown, allergic inflammation is dramatically alleviated. Furthermore, we demonstrated that BLT2 mediates the synthesis of vascular endothelial growth factor (VEGF) and Th2 cytokines, such as interleukin (IL)-13, in mast cells during allergic inflammation. Based on the critical roles of BLT2 in mast cells in allergic inflammation, anti-BLT2 strategies could contribute to the development of new therapies for allergic airway inflammation.

Original languageEnglish
JournalInternational journal of molecular sciences
Volume20
Issue number12
DOIs
Publication statusPublished - 2019 Jun 14

Fingerprint

Leukotriene B4 Receptors
Mast Cells
Inflammation
pathogenesis
interleukins
effectors
immune systems
Interleukin-13
Immune system
Vascular Endothelial Growth Factor A
affinity
therapy
Cytokines
synthesis
cells
Immune System
Down-Regulation

Keywords

  • allergic airway inflammation
  • asthma
  • leukotriene B4 receptor-2
  • mast cells

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation. / Kwon, Sun Young; Kim, Jae-Hong.

In: International journal of molecular sciences, Vol. 20, No. 12, 14.06.2019.

Research output: Contribution to journalArticle

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