Role of Nicotinic acetylcholine receptor on efferent inhibition in cochlear hair cell

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalKorean Journal of Audiology
Volume16
Issue number3
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Auditory Hair Cells
Nicotinic Receptors
Cochlea
Calcium
Calcium-Activated Potassium Channels
Permeability

Keywords

  • Acetylcholine
  • Calcium
  • Cochlea
  • Hair cell
  • Nicotinic receptor

ASJC Scopus subject areas

  • Sensory Systems
  • Speech and Hearing

Cite this

Role of Nicotinic acetylcholine receptor on efferent inhibition in cochlear hair cell. / Im, Gi Jung.

In: Korean Journal of Audiology, Vol. 16, No. 3, 01.12.2012, p. 108-113.

Research output: Contribution to journalReview article

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AB - The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system

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