Role of Nicotinic acetylcholine receptor on efferent inhibition in cochlear hair cell

Gi Jung Im

    Research output: Contribution to journalReview articlepeer-review

    1 Citation (Scopus)

    Abstract

    The α9α10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system

    Original languageEnglish
    Pages (from-to)108-113
    Number of pages6
    JournalKorean Journal of Audiology
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 2012 Dec

    Keywords

    • Acetylcholine
    • Calcium
    • Cochlea
    • Hair cell
    • Nicotinic receptor

    ASJC Scopus subject areas

    • Sensory Systems
    • Speech and Hearing

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