Abstract
Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e.; genetic rat models, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e.; impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 122-137 |
| Number of pages | 16 |
| Journal | Neurochemistry International |
| Volume | 59 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 Aug 1 |
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Keywords
- Animal models
- Antioxidant strategies
- Epileptic seizures
- Oxidative stress
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology
Cite this
Role of oxidative stress in epileptic seizures. / Shin, Eun Joo; Jeong, Ji Hoon; Chung, Yoon Hee; Kim, Won-Ki; Ko, Kwang Ho; Bach, Jae Hyung; Hong, Jau Shyong; Yoneda, Yukio; Kim, Hyoung Chun.
In: Neurochemistry International, Vol. 59, No. 2, 01.08.2011, p. 122-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of oxidative stress in epileptic seizures
AU - Shin, Eun Joo
AU - Jeong, Ji Hoon
AU - Chung, Yoon Hee
AU - Kim, Won-Ki
AU - Ko, Kwang Ho
AU - Bach, Jae Hyung
AU - Hong, Jau Shyong
AU - Yoneda, Yukio
AU - Kim, Hyoung Chun
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e.; genetic rat models, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e.; impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.
AB - Oxidative stress resulting from excessive free-radical release is likely implicated in the initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing oxidative stress have received considerable attention in epilepsy treatment. However, much evidence suggests that oxidative stress does not always have the same pattern in all seizures models. Thus, this review provides an overview aimed at achieving a better understanding of this issue. We summarize work regarding seizure models (i.e.; genetic rat models, kainic acid, pilocarpine, pentylenetetrazol, and trimethyltin), oxidative stress as an etiologic factor in epileptic seizures (i.e.; impairment of antioxidant systems, mitochondrial dysfunction, involvement of redox-active metals, arachidonic acid pathway activation, and aging), and antioxidant strategies for seizure treatment. Combined, this review highlights pharmacological mechanisms associated with oxidative stress in epileptic seizures and the potential for neuroprotection in epilepsy that targets oxidative stress and is supported by effective antioxidant treatment.
KW - Animal models
KW - Antioxidant strategies
KW - Epileptic seizures
KW - Oxidative stress
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U2 - 10.1016/j.neuint.2011.03.025
DO - 10.1016/j.neuint.2011.03.025
M3 - Article
C2 - 21672578
AN - SCOPUS:79960365658
VL - 59
SP - 122
EP - 137
JO - Neurochemistry International
JF - Neurochemistry International
SN - 0197-0186
IS - 2
ER -