Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

Jung Hyun Park, Du Hyong Cho, Cheol-Won Yun, Jae W. Soh, Young Mee Jee, Sang I. Park, Inho Jo, Jae Hwan Nam

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.

Original languageEnglish
Pages (from-to)550-555
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume16
Issue number4
Publication statusPublished - 2006 Apr 1

Fingerprint

Enterovirus
Cell death
HeLa Cells
Protein Kinase C
Apoptosis
Proteins
Signal transduction
Mitochondria
Pathogens
Cell Death
Infection
Myocarditis
Dilated Cardiomyopathy
Signal Transduction

Keywords

  • Apoptosis
  • CVB3
  • PKC δ

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Park, J. H., Cho, D. H., Yun, C-W., Soh, J. W., Jee, Y. M., Park, S. I., ... Nam, J. H. (2006). Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells. Journal of Microbiology and Biotechnology, 16(4), 550-555.

Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells. / Park, Jung Hyun; Cho, Du Hyong; Yun, Cheol-Won; Soh, Jae W.; Jee, Young Mee; Park, Sang I.; Jo, Inho; Nam, Jae Hwan.

In: Journal of Microbiology and Biotechnology, Vol. 16, No. 4, 01.04.2006, p. 550-555.

Research output: Contribution to journalArticle

Park, JH, Cho, DH, Yun, C-W, Soh, JW, Jee, YM, Park, SI, Jo, I & Nam, JH 2006, 'Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells', Journal of Microbiology and Biotechnology, vol. 16, no. 4, pp. 550-555.
Park, Jung Hyun ; Cho, Du Hyong ; Yun, Cheol-Won ; Soh, Jae W. ; Jee, Young Mee ; Park, Sang I. ; Jo, Inho ; Nam, Jae Hwan. / Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells. In: Journal of Microbiology and Biotechnology. 2006 ; Vol. 16, No. 4. pp. 550-555.
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