Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells

Jung Hyun Park, Du Hyong Cho, Cheol-Won Yun, Jae W. Soh, Young Mee Jee, Sang I. Park, Inho Jo, Jae Hwan Nam

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2 Citations (Scopus)

Abstract

CVB3 is a virulent human pathogen that induces myocarditis and ultimately dilated cardiomyopathy. Although several apoptotic factors are involved in the cell death induced by CVB3, the upstream signal transduction factors of CVB3-induced apoptosis are still unclear. We explored and characterized the role of PKC δ in CVB3-infected cells. PKC δ was cleaved after CVB3 infection and was activated at 6 h postinfection. PKC δ was also translocated into the nucleus via mitochondria after CVB3 infection, and overexpression of wild-type PKC δ reduced the apoptotic cell death caused by CVB3. These results indicate that PKC δ has an anti-apoptotic role in CVB3 infection.

Original languageEnglish
Pages (from-to)550-555
Number of pages6
JournalJournal of Microbiology and Biotechnology
Volume16
Issue number4
Publication statusPublished - 2006 Apr 1

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Keywords

  • Apoptosis
  • CVB3
  • PKC δ

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Park, J. H., Cho, D. H., Yun, C-W., Soh, J. W., Jee, Y. M., Park, S. I., Jo, I., & Nam, J. H. (2006). Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells. Journal of Microbiology and Biotechnology, 16(4), 550-555.