Role of Rho GTPase in the endothelin-1-induced nuclear signaling

Jae-Hong Kim, Yong Suk Cho, Byung Chul Kim, Yong Sun Kim, Gil Soo Lee

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18 Citations (Scopus)

Abstract

Binding of Endothelin-1 (ET-1) to its heterotrimeric G protein-coupled receptors stimulates various signaling cascades involving the activation of phospholipase C-β, phospholipase D, protein kinase C (PKC), tyrosine kinases, Ca 2+/calmodulin-dependent kinase (CaMKs), and Ras, a small molecular weight G-protein, but, the role of Rho GTPase remains unclear. In this project, we examined whether RhoA contributes to the ET-1-induced signaling cascade to c-fos SRE activation in Rat-2 fibroblast cells. Our results demonstrate that Rho activation is critical for the signal transduction of ET-1 to c-fos SRE.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume232
Issue number1
DOIs
Publication statusPublished - 1997 Mar 6
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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