Role of Rho GTPase in the endothelin-1-induced nuclear signaling

Jae-Hong Kim, Yong Suk Cho, Byung Chul Kim, Yong Sun Kim, Gil Soo Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Binding of Endothelin-1 (ET-1) to its heterotrimeric G protein-coupled receptors stimulates various signaling cascades involving the activation of phospholipase C-β, phospholipase D, protein kinase C (PKC), tyrosine kinases, Ca 2+/calmodulin-dependent kinase (CaMKs), and Ras, a small molecular weight G-protein, but, the role of Rho GTPase remains unclear. In this project, we examined whether RhoA contributes to the ET-1-induced signaling cascade to c-fos SRE activation in Rat-2 fibroblast cells. Our results demonstrate that Rho activation is critical for the signal transduction of ET-1 to c-fos SRE.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume232
Issue number1
DOIs
Publication statusPublished - 1997 Mar 6
Externally publishedYes

Fingerprint

rho GTP-Binding Proteins
Endothelin-1
Chemical activation
TYK2 Kinase
Heterotrimeric GTP-Binding Proteins
Phospholipase D
Signal transduction
Calcium-Calmodulin-Dependent Protein Kinases
Type C Phospholipases
Calmodulin
Fibroblasts
G-Protein-Coupled Receptors
GTP-Binding Proteins
Protein-Tyrosine Kinases
Protein Kinase C
Rats
Signal Transduction
Phosphotransferases
Molecular Weight
Molecular weight

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Role of Rho GTPase in the endothelin-1-induced nuclear signaling. / Kim, Jae-Hong; Cho, Yong Suk; Kim, Byung Chul; Kim, Yong Sun; Lee, Gil Soo.

In: Biochemical and Biophysical Research Communications, Vol. 232, No. 1, 06.03.1997, p. 223-226.

Research output: Contribution to journalArticle

Kim, Jae-Hong ; Cho, Yong Suk ; Kim, Byung Chul ; Kim, Yong Sun ; Lee, Gil Soo. / Role of Rho GTPase in the endothelin-1-induced nuclear signaling. In: Biochemical and Biophysical Research Communications. 1997 ; Vol. 232, No. 1. pp. 223-226.
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