Role of signals from the dorsal root ganglion in neuropathic pain in a rat model

Heung Sik Na, Kyung Hee Ko, Seung Keun Back, Backil Sung, Dong Jin Yoo, Seung Kil Hong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We examined whether signals from the neuroma or the dorsal root ganglion of the injured segment are critical for the generation of neuropathic pain. To this aim, we used a rat model of peripheral neuropathy made by transecting the inferior and superior caudal trunks at the level between the S1 and S2 spinal nerves under enflurane anesthesia. These animals displayed tail-withdrawal responses to normally innocuous mechanical stimulation applied to the tail with a von Frey hair (2 g). Also, these animals, compared to pre-surgical value, displayed shorter tail-withdrawal latencies following immersion of the tail to warm (40°C) or cold (4°C) water. Transection of the S1 spinal nerve between the dorsal root ganglion and neuroma did not change the behavioral signs of neuropathic pain. In contrast, S1 dorsal rhizotomy significantly reduced the behavioral signs. The data suggest that signals arising from the dorsal root ganglion cells of the injured segment, but not from the neuroma, are critical for the generation of neuropathic pain in this model. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalNeuroscience Letters
Volume288
Issue number2
DOIs
Publication statusPublished - 2000 Jul 14

Keywords

  • Allodynia
  • Dorsal root ganglion
  • Injured afferents
  • Neuroma
  • Neuropathic pain
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)

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