Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

Seung-Kuk Baek, Myung Chul Lee, J. Hun Hah, Soon Hyun Ahn, Young Ik Son, Young Soo Rho, Phil Sang Chung, Yoon Se Lee, Bon Seok Koo, Kwang-Yoon Jung, Byung Joo Lee

Research output: Contribution to journalArticle

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Abstract

Background: The Korean Society of Thyroid Head and Neck Surgery established a nationwide multicenter registry of anaplastic thyroid carcinoma (ATC) and evaluated the prognostic factors and treatment outcomes of ATC. Methods: The present study enrolled 329 patients who were diagnosed with ATC between January 2000 and December 2012 at 19 medical centers in Korea. Survival outcomes were evaluated according to various clinical factors and treatments. Results: Multivariate analysis identified age ≥70 years old, the presence of initial clinical symptoms, distant metastasis, and treatment modality as significant risk factors (p <.05). The patients who underwent curative resection and adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT) showed the best survival on multivariate analysis (p < 0.05). Conclusion: Although ATC is a lethal neoplasm, long-term survival may be acquired in cases in which the aggressive management, including curative resection or RT/concurrent CRT, is possible for therapeutic intent.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalHead and Neck
Volume39
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Multicenter Studies
Chemoradiotherapy
Survival
Multivariate Analysis
Adjuvant Chemoradiotherapy
Adjuvant Radiotherapy
Korea
Registries
Thyroid Gland
Neck
Radiotherapy
Therapeutics
Neoplasm Metastasis
Anaplastic Thyroid Carcinoma
Neoplasms

Keywords

  • anaplastic thyroid carcinoma
  • multicenter study
  • multimodal treatment
  • prognostic factor
  • surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Role of surgery in the management of anaplastic thyroid carcinoma : Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012. / Baek, Seung-Kuk; Lee, Myung Chul; Hah, J. Hun; Ahn, Soon Hyun; Son, Young Ik; Rho, Young Soo; Chung, Phil Sang; Lee, Yoon Se; Koo, Bon Seok; Jung, Kwang-Yoon; Lee, Byung Joo.

In: Head and Neck, Vol. 39, No. 1, 01.01.2017, p. 133-139.

Research output: Contribution to journalArticle

Baek, Seung-Kuk ; Lee, Myung Chul ; Hah, J. Hun ; Ahn, Soon Hyun ; Son, Young Ik ; Rho, Young Soo ; Chung, Phil Sang ; Lee, Yoon Se ; Koo, Bon Seok ; Jung, Kwang-Yoon ; Lee, Byung Joo. / Role of surgery in the management of anaplastic thyroid carcinoma : Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012. In: Head and Neck. 2017 ; Vol. 39, No. 1. pp. 133-139.
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AU - Rho, Young Soo

AU - Chung, Phil Sang

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