Abstract
Objective: To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods: A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results: Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions: Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.
| Original language | English |
|---|---|
| Pages (from-to) | 2951-2957 |
| Number of pages | 7 |
| Journal | Annals of Surgical Oncology |
| Volume | 17 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2010 Nov 1 |
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ASJC Scopus subject areas
- Surgery
- Oncology
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Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer. / Jeong, Nan Hee; Lee, Jong Min; Lee, Jae Kwan; Kim, Mi Kyung; Kim, Young Jae; Cho, Chi Heum; Kim, Seok Mo; Park, Sang Yoon; Park, Chan Yong; Kim, Ki Tae.
In: Annals of Surgical Oncology, Vol. 17, No. 11, 01.11.2010, p. 2951-2957.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer
AU - Jeong, Nan Hee
AU - Lee, Jong Min
AU - Lee, Jae Kwan
AU - Kim, Mi Kyung
AU - Kim, Young Jae
AU - Cho, Chi Heum
AU - Kim, Seok Mo
AU - Park, Sang Yoon
AU - Park, Chan Yong
AU - Kim, Ki Tae
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Objective: To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods: A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results: Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions: Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.
AB - Objective: To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods: A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results: Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions: Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.
UR - http://www.scopus.com/inward/record.url?scp=78049476170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049476170&partnerID=8YFLogxK
U2 - 10.1245/s10434-010-1169-y
DO - 10.1245/s10434-010-1169-y
M3 - Article
C2 - 20556522
AN - SCOPUS:78049476170
VL - 17
SP - 2951
EP - 2957
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 11
ER -