Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer

Nan Hee Jeong, Jong Min Lee, Jae Kwan Lee, Mi Kyung Kim, Young Jae Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim

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    9 Citations (Scopus)

    Abstract

    Objective: To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods: A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results: Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions: Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.

    Original languageEnglish
    Pages (from-to)2951-2957
    Number of pages7
    JournalAnnals of Surgical Oncology
    Volume17
    Issue number11
    DOIs
    Publication statusPublished - 2010 Nov

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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