Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer

Nan Hee Jeong, Jong Min Lee, Jae Kwan Lee, Mi Kyung Kim, Young Jae Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Chan Yong Park, Ki Tae Kim

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the roles of lymphadenectomy in endometrioid uterine cancer patients and adjuvant radiation in early-stage endometrioid uterine cancer patients who underwent systematic lymphadenectomy. Methods: A retrospective analysis of 758 patients surgically treated for early-stage endometrioid uterine cancer from 2000 to 2006 was conducted. The primary outcome was 5-year overall survival in relation to systematic lymphadenectomy with or without adjuvant radiation. Results: Of the 758 patients, 547 (72.2%) underwent complete surgical staging, including systematic lymphadenectomy; adjuvant radiation was administered to 207 patients (27.3%). Within median follow-up of 35 months, systematic lymphadenectomy did not affect overall survival in early-stage patients (P = 0.4480). In the high-risk, early-stage group, however, the 5-year survival rate of the systematic lymphadenectomy group showed better survival compared with the no systematic lymphadenectomy group (P = 0.0095). Also, adjuvant radiation did not affect overall survival in early-stage patients (P = 0.1170), even in the group of high-risk, early-stage patients (P = 0.5680) who underwent systematic lymphadenectomy. Conclusions: Systematic lymphadenectomy provided a survival benefit in high-risk endometrioid uterine cancer patients. However, in patients who underwent systematic lymphadenectomy, adjuvant radiation was not beneficial, even in high-risk patients.

Original languageEnglish
Pages (from-to)2951-2957
Number of pages7
JournalAnnals of Surgical Oncology
Volume17
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

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Uterine Neoplasms
Lymph Node Excision
Radiation
Survival
Survival Rate

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer. / Jeong, Nan Hee; Lee, Jong Min; Lee, Jae Kwan; Kim, Mi Kyung; Kim, Young Jae; Cho, Chi Heum; Kim, Seok Mo; Park, Sang Yoon; Park, Chan Yong; Kim, Ki Tae.

In: Annals of Surgical Oncology, Vol. 17, No. 11, 01.11.2010, p. 2951-2957.

Research output: Contribution to journalArticle

Jeong, NH, Lee, JM, Lee, JK, Kim, MK, Kim, YJ, Cho, CH, Kim, SM, Park, SY, Park, CY & Kim, KT 2010, 'Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer', Annals of Surgical Oncology, vol. 17, no. 11, pp. 2951-2957. https://doi.org/10.1245/s10434-010-1169-y
Jeong, Nan Hee ; Lee, Jong Min ; Lee, Jae Kwan ; Kim, Mi Kyung ; Kim, Young Jae ; Cho, Chi Heum ; Kim, Seok Mo ; Park, Sang Yoon ; Park, Chan Yong ; Kim, Ki Tae. / Role of systematic lymphadenectomy and adjuvant radiation in early-stage endometrioid uterine cancer. In: Annals of Surgical Oncology. 2010 ; Vol. 17, No. 11. pp. 2951-2957.
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