Roles of erythroid differentiation regulator 1 (Erdr1) on inflammatory skin diseases

Youn Kyung Houh, Kyung Eun Kim, Hyun Jeong Park, Dae Ho Cho

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

Original languageEnglish
Article number2059
JournalInternational journal of molecular sciences
Volume17
Issue number12
DOIs
Publication statusPublished - 2016 Dec 8
Externally publishedYes

Keywords

  • Cutaneous inflammation
  • Erdr1
  • IL-18
  • Melanoma
  • Psoriasis
  • Rosacea

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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