Roles of erythroid differentiation regulator 1 (Erdr1) on inflammatory skin diseases

Youn Kyung Houh; Kyung Eun Kim; Hyun Jeong Park; Daeho Cho

doi:10.3390/ijms17122059

Roles of erythroid differentiation regulator 1 (Erdr1) on inflammatory skin diseases

Youn Kyung Houh, Kyung Eun Kim, Hyun Jeong Park, Daeho Cho

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

Original language	English
Article number	2059
Journal	International journal of molecular sciences
Volume	17
Issue number	12
DOIs	https://doi.org/10.3390/ijms17122059
Publication status	Published - 2016 Dec 8
Externally published	Yes

Keywords

Cutaneous inflammation
Erdr1
IL-18
Melanoma
Psoriasis
Rosacea

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms17122059

Cite this

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title = "Roles of erythroid differentiation regulator 1 (Erdr1) on inflammatory skin diseases",

abstract = "Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.",

keywords = "Cutaneous inflammation, Erdr1, IL-18, Melanoma, Psoriasis, Rosacea",

author = "Houh, {Youn Kyung} and Kim, {Kyung Eun} and Park, {Hyun Jeong} and Daeho Cho",

note = "Funding Information: This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2016M3D1A1021387) and Basic Science Research Program through the NRF funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2062797). Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

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doi = "10.3390/ijms17122059",

language = "English",

volume = "17",

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AU - Houh, Youn Kyung

AU - Kim, Kyung Eun

AU - Park, Hyun Jeong

AU - Cho, Daeho

N1 - Funding Information: This research was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (2016M3D1A1021387) and Basic Science Research Program through the NRF funded by the Ministry of Education, Science and Technology (NRF-2013R1A1A2062797). Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2016/12/8

Y1 - 2016/12/8

N2 - Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

AB - Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

KW - Cutaneous inflammation

KW - Erdr1

KW - IL-18

KW - Melanoma

KW - Psoriasis

KW - Rosacea

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U2 - 10.3390/ijms17122059

DO - 10.3390/ijms17122059

M3 - Review article

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AN - SCOPUS:85006132388

SN - 1661-6596

VL - 17

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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M1 - 2059

ER -

Roles of erythroid differentiation regulator 1 (Erdr1) on inflammatory skin diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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