Roles of semaphorins in the immune and hematopoietic system

Jong Dae Ji, Lionel B. Ivashkiv

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Semaphorins were originally discovered in the nervous system, and have been implicated in repulsive axon guidance during the development of nervous system. Semaphorins are also implicated in tumor progression, by affecting adhesion, migration of malignant cells and angiogenesis, and are involved in normal cardiovascular development. Recently, several semaphorins and their receptors are expressed in a variety of lymphoid and myeloid cells, and affect immune cell functions, including cell proliferation, differentiation, chemotaxis, and cytokine production. This review focuses on recent work on the functions of semaphorins in the immune system and autoimmune diseases.

Original languageEnglish
Pages (from-to)727-734
Number of pages8
JournalRheumatology International
Volume29
Issue number7
DOIs
Publication statusPublished - 2009 May

Keywords

  • Autoimmunity
  • Immune system
  • Neuropilins
  • Plexins
  • Semaphorins

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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