Roles of semaphorins in the immune and hematopoietic system

Jong Dae Ji, Lionel B. Ivashkiv

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)

    Abstract

    Semaphorins were originally discovered in the nervous system, and have been implicated in repulsive axon guidance during the development of nervous system. Semaphorins are also implicated in tumor progression, by affecting adhesion, migration of malignant cells and angiogenesis, and are involved in normal cardiovascular development. Recently, several semaphorins and their receptors are expressed in a variety of lymphoid and myeloid cells, and affect immune cell functions, including cell proliferation, differentiation, chemotaxis, and cytokine production. This review focuses on recent work on the functions of semaphorins in the immune system and autoimmune diseases.

    Original languageEnglish
    Pages (from-to)727-734
    Number of pages8
    JournalRheumatology International
    Volume29
    Issue number7
    DOIs
    Publication statusPublished - 2009 May

    Keywords

    • Autoimmunity
    • Immune system
    • Neuropilins
    • Plexins
    • Semaphorins

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Rheumatology
    • Immunology

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