Romo1 and the NF-κB pathway are involved in oxidative stress-induced tumor cell invasion

Sora Lee, Yoon Hee Park, Jin Sil Chung, Young Do Yoo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are important contributors to tumor cell invasion. ROS enhanced by reactive oxygen species modulator 1 (Romo1) expression has been reported to increase invasive potential and constitutive activation of nuclear factor-κB (NF-κB) in hepatocellular carcinoma (HCC). Therefore, we investigated whether constitutive NF-κB activation due to Romo1 expression is associated with breast cancer tumor cell invasion. In this study, we show that oxidative stress-induced invasion is mediated by Romo1 expression. The Romo1-induced increase of invasive activity was blocked by an inhibitor of κB kinase (IKK). These results demonstrate that tumor cell invasion in response to oxidative stress is associated with Romo1 expression and the NF-κB signaling pathway. Romo1 is therefore a promising therapeutic target for diseases characterized by NF-κB deregulation.

Original languageEnglish
Pages (from-to)2021-2028
Number of pages8
JournalInternational Journal of Oncology
Volume46
Issue number5
DOIs
Publication statusPublished - 2015 May 1

Keywords

  • Nuclear factor-κB
  • Oxidative stress
  • Reactive oxygen species
  • Romo1
  • Tumor invasion

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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