RORA polymorphism interacts with childhood maltreatment in determining anxiety sensitivity by sex: A preliminary study in healthy young adults

Jung Ah Min, Heon-Jeong Lee, Seung Hwan Lee, Young Min Park, Seung Gul Kang, Young Gyu Park, Jeong Ho Chae

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders. Methods: Two-hundred and five healthy young Korean adults (female: 98, male: 107; age, 23.0±3.2 years) completed genotyping for the RORA SNP rs11071547, as well as measures for AS and CM. Generalized linear models were used to examine the main and interaction effects of RORA genotype, CM, and sex in determining AS. Results: The main effect of RORA polymorphisms was not found (p=0.760) whereas the main effect of CM and interaction effects among sex, genotype, and maltreatment were significant on AS. In separate analyses by sex, the interaction effect between RORA genotype and maltreatment was significant only in males (p<0.001). In females, the main effects of genotype and CM were significant (both were p<0.001), in which both a history of CM and C genotype tended to be associated with higher AS. Conclusion: The association between RORA polymorphism and AS might differ by sex. The interaction between RORA polymorphism and CM was significant only in males whereas RORA genotype and CM independently associated with AS in females. Further studies are encouraged to confirm the relationship between RORA polymorphism and AS.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalClinical Psychopharmacology and Neuroscience
Volume15
Issue number4
DOIs
Publication statusPublished - 2017

Fingerprint

Young Adult
Anxiety
Genotype
Anxiety Disorders
Nuclear Receptor Subfamily 1, Group F, Member 1
Single Nucleotide Polymorphism
Depression
Gene-Environment Interaction
Sex Characteristics
Linear Models
Phenotype
Genes

Keywords

  • Anxiety sensitivity
  • Childhood trauma
  • Gene-environment interaction
  • Retinoid acid receptor-related orphan receptor alpha (RORA) gene
  • Sex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Pharmacology (medical)

Cite this

RORA polymorphism interacts with childhood maltreatment in determining anxiety sensitivity by sex : A preliminary study in healthy young adults. / Min, Jung Ah; Lee, Heon-Jeong; Lee, Seung Hwan; Park, Young Min; Kang, Seung Gul; Park, Young Gyu; Chae, Jeong Ho.

In: Clinical Psychopharmacology and Neuroscience, Vol. 15, No. 4, 2017, p. 402-406.

Research output: Contribution to journalArticle

Min, Jung Ah ; Lee, Heon-Jeong ; Lee, Seung Hwan ; Park, Young Min ; Kang, Seung Gul ; Park, Young Gyu ; Chae, Jeong Ho. / RORA polymorphism interacts with childhood maltreatment in determining anxiety sensitivity by sex : A preliminary study in healthy young adults. In: Clinical Psychopharmacology and Neuroscience. 2017 ; Vol. 15, No. 4. pp. 402-406.
@article{655e0620e0354cbe80b1891497930a4b,
title = "RORA polymorphism interacts with childhood maltreatment in determining anxiety sensitivity by sex: A preliminary study in healthy young adults",
abstract = "Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders. Methods: Two-hundred and five healthy young Korean adults (female: 98, male: 107; age, 23.0±3.2 years) completed genotyping for the RORA SNP rs11071547, as well as measures for AS and CM. Generalized linear models were used to examine the main and interaction effects of RORA genotype, CM, and sex in determining AS. Results: The main effect of RORA polymorphisms was not found (p=0.760) whereas the main effect of CM and interaction effects among sex, genotype, and maltreatment were significant on AS. In separate analyses by sex, the interaction effect between RORA genotype and maltreatment was significant only in males (p<0.001). In females, the main effects of genotype and CM were significant (both were p<0.001), in which both a history of CM and C genotype tended to be associated with higher AS. Conclusion: The association between RORA polymorphism and AS might differ by sex. The interaction between RORA polymorphism and CM was significant only in males whereas RORA genotype and CM independently associated with AS in females. Further studies are encouraged to confirm the relationship between RORA polymorphism and AS.",
keywords = "Anxiety sensitivity, Childhood trauma, Gene-environment interaction, Retinoid acid receptor-related orphan receptor alpha (RORA) gene, Sex",
author = "Min, {Jung Ah} and Heon-Jeong Lee and Lee, {Seung Hwan} and Park, {Young Min} and Kang, {Seung Gul} and Park, {Young Gyu} and Chae, {Jeong Ho}",
year = "2017",
doi = "10.9758/cpn.2017.15.4.402",
language = "English",
volume = "15",
pages = "402--406",
journal = "Clinical Psychopharmacology and Neuroscience",
issn = "1738-1088",
publisher = "Korean College of Neuropsychopharmacology",
number = "4",

}

TY - JOUR

T1 - RORA polymorphism interacts with childhood maltreatment in determining anxiety sensitivity by sex

T2 - A preliminary study in healthy young adults

AU - Min, Jung Ah

AU - Lee, Heon-Jeong

AU - Lee, Seung Hwan

AU - Park, Young Min

AU - Kang, Seung Gul

AU - Park, Young Gyu

AU - Chae, Jeong Ho

PY - 2017

Y1 - 2017

N2 - Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders. Methods: Two-hundred and five healthy young Korean adults (female: 98, male: 107; age, 23.0±3.2 years) completed genotyping for the RORA SNP rs11071547, as well as measures for AS and CM. Generalized linear models were used to examine the main and interaction effects of RORA genotype, CM, and sex in determining AS. Results: The main effect of RORA polymorphisms was not found (p=0.760) whereas the main effect of CM and interaction effects among sex, genotype, and maltreatment were significant on AS. In separate analyses by sex, the interaction effect between RORA genotype and maltreatment was significant only in males (p<0.001). In females, the main effects of genotype and CM were significant (both were p<0.001), in which both a history of CM and C genotype tended to be associated with higher AS. Conclusion: The association between RORA polymorphism and AS might differ by sex. The interaction between RORA polymorphism and CM was significant only in males whereas RORA genotype and CM independently associated with AS in females. Further studies are encouraged to confirm the relationship between RORA polymorphism and AS.

AB - Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders. Methods: Two-hundred and five healthy young Korean adults (female: 98, male: 107; age, 23.0±3.2 years) completed genotyping for the RORA SNP rs11071547, as well as measures for AS and CM. Generalized linear models were used to examine the main and interaction effects of RORA genotype, CM, and sex in determining AS. Results: The main effect of RORA polymorphisms was not found (p=0.760) whereas the main effect of CM and interaction effects among sex, genotype, and maltreatment were significant on AS. In separate analyses by sex, the interaction effect between RORA genotype and maltreatment was significant only in males (p<0.001). In females, the main effects of genotype and CM were significant (both were p<0.001), in which both a history of CM and C genotype tended to be associated with higher AS. Conclusion: The association between RORA polymorphism and AS might differ by sex. The interaction between RORA polymorphism and CM was significant only in males whereas RORA genotype and CM independently associated with AS in females. Further studies are encouraged to confirm the relationship between RORA polymorphism and AS.

KW - Anxiety sensitivity

KW - Childhood trauma

KW - Gene-environment interaction

KW - Retinoid acid receptor-related orphan receptor alpha (RORA) gene

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=85032723544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032723544&partnerID=8YFLogxK

U2 - 10.9758/cpn.2017.15.4.402

DO - 10.9758/cpn.2017.15.4.402

M3 - Article

AN - SCOPUS:85032723544

VL - 15

SP - 402

EP - 406

JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

SN - 1738-1088

IS - 4

ER -