ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

Dong Gil You, V. G. Deepagan, Wooram Um, Sangmin Jeon, Sejin Son, Hyeyoun Chang, Hwa In Yoon, Yong Woo Cho, Maggie Swierczewska, Seulki Lee, Martin G. Pomper, Ick Chan Kwon, Kwang Meyung Kim, Jae Hyung Park

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo.

Original languageEnglish
Article number23200
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Mar 21
Externally publishedYes

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Nanoparticles
Reactive Oxygen Species
Neoplasms
Photochemotherapy
Therapeutics
Growth
Blood Vessels
Cytokines
Light
Liver

ASJC Scopus subject areas

  • General

Cite this

You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., ... Park, J. H. (2016). ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer. Scientific Reports, 6, [23200]. https://doi.org/10.1038/srep23200

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer. / You, Dong Gil; Deepagan, V. G.; Um, Wooram; Jeon, Sangmin; Son, Sejin; Chang, Hyeyoun; Yoon, Hwa In; Cho, Yong Woo; Swierczewska, Maggie; Lee, Seulki; Pomper, Martin G.; Kwon, Ick Chan; Kim, Kwang Meyung; Park, Jae Hyung.

In: Scientific Reports, Vol. 6, 23200, 21.03.2016.

Research output: Contribution to journalArticle

You, DG, Deepagan, VG, Um, W, Jeon, S, Son, S, Chang, H, Yoon, HI, Cho, YW, Swierczewska, M, Lee, S, Pomper, MG, Kwon, IC, Kim, KM & Park, JH 2016, 'ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer', Scientific Reports, vol. 6, 23200. https://doi.org/10.1038/srep23200
You, Dong Gil ; Deepagan, V. G. ; Um, Wooram ; Jeon, Sangmin ; Son, Sejin ; Chang, Hyeyoun ; Yoon, Hwa In ; Cho, Yong Woo ; Swierczewska, Maggie ; Lee, Seulki ; Pomper, Martin G. ; Kwon, Ick Chan ; Kim, Kwang Meyung ; Park, Jae Hyung. / ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer. In: Scientific Reports. 2016 ; Vol. 6.
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