Rosacea: Molecular mechanisms and management of a chronic cutaneous inflammatory condition

Yu Ri Woo, Ji Hong Lim, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. We describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology. Understanding the molecular pathomechanisms of rosacea will likely aid toward better comprehending its complex pathogenesis.

Original languageEnglish
Article number1562
JournalInternational journal of molecular sciences
Volume17
Issue number9
DOIs
Publication statusPublished - 2016 Sep 15
Externally publishedYes

Keywords

  • Genetic
  • Immune defect
  • Inflammation
  • Neurovascular dysregulation
  • Rosacea
  • Triggering factor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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