Routine pulmonary function test can estimate the extent of tuberculous destroyed lung

Eun Joo Lee, Sang Yeub Lee, Kwang Ho In, Se Hwa Yoo, Eun Jeong Choi, Yu Whan Oh, Sanghoon Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Tuberculous destroyed lung (TDL) is diagnosed by a clear past history of tuberculosis with findings of parenchymal destruction verified by chest X-ray. Despite the resultant deterioration of lung function and quality of lives seen in TDL patients, the exact mechanism or characteristics of pulmonary function worsening have not been clearly studied. We investigated the feature of respiratory impairment of TDL patients, and studied whether extent of destroyed lung measured with chest CT has any correlation with routine lung function. To evaluate the degree of destruction, the Goddard classification scoring system was modified into a novel scoring system (destroyed lung score, (DLS)) with a score from 0 to 4. Twenty-five subjects were enrolled. TDL predominantly manifested as an obstructive pattern (64%, 16/25). Median value of DLS of the entire lung was 2.6 (1.73.9). Absolute values of FEV1 and FVC were both negatively associated with DLS (r = - 0.78, P = 0.001, and r = - 0.61, P = 0.021). Percentage of predicted value of FEV1 and FVC were also negatively associated with DLS (r = - 0.62, P = 0.019, and r = - 0.76, P = 0.002). Our study shows that lung function of TDL patients were notably correlated with the extent of destroyed lung measured with chest CT scan.

Original languageEnglish
Article number835031
JournalThe Scientific World Journal
Volume2012
DOIs
Publication statusPublished - 2012 Jun 21

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tuberculosis
Respiratory Function Tests
quality of life
Lung
history
Computerized tomography
Deterioration
X rays
Thorax
test

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Routine pulmonary function test can estimate the extent of tuberculous destroyed lung. / Lee, Eun Joo; Lee, Sang Yeub; In, Kwang Ho; Yoo, Se Hwa; Choi, Eun Jeong; Oh, Yu Whan; Park, Sanghoon.

In: The Scientific World Journal, Vol. 2012, 835031, 21.06.2012.

Research output: Contribution to journalArticle

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