RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

Chang Young Jang; Jae Yung Lee; Joon Kim

doi:10.1016/S0014-5793(04)00074-2

RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

Chang Young Jang, Jae Yung Lee, Joon Kim

Division of Life Sciences

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.

Original language	English
Pages (from-to)	81-85
Number of pages	5
Journal	FEBS Letters
Volume	560
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(04)00074-2
Publication status	Published - 2004 Feb 27

Keywords

Apoptosis
Cytokine
DNA repair
Lymphocyte
rpS3

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/S0014-5793(04)00074-2

Fingerprint Dive into the research topics of 'RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis'. Together they form a unique fingerprint.

Cite this

@article{b50c910dfbcd4d81b2c63f402cd97a30,

title = "RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis",

abstract = "It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.",

keywords = "Apoptosis, Cytokine, DNA repair, Lymphocyte, rpS3",

author = "Jang, {Chang Young} and Lee, {Jae Yung} and Joon Kim",

note = "Funding Information: This work was supported in part by a KOSEF grant (KOSEF-99-1-209-005-5) from the Ministry of Science and Technology of Korea.",

year = "2004",

month = feb,

day = "27",

doi = "10.1016/S0014-5793(04)00074-2",

language = "English",

volume = "560",

pages = "81--85",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

AU - Jang, Chang Young

AU - Lee, Jae Yung

AU - Kim, Joon

N1 - Funding Information: This work was supported in part by a KOSEF grant (KOSEF-99-1-209-005-5) from the Ministry of Science and Technology of Korea.

PY - 2004/2/27

Y1 - 2004/2/27

N2 - It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.

AB - It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.

KW - Apoptosis

KW - Cytokine

KW - DNA repair

KW - Lymphocyte

KW - rpS3

UR - http://www.scopus.com/inward/record.url?scp=1342265497&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(04)00074-2

DO - 10.1016/S0014-5793(04)00074-2

M3 - Article

C2 - 14988002

AN - SCOPUS:1342265497

VL - 560

SP - 81

EP - 85

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1-3

ER -

RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this