RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

Chang Young Jang, Jae Yung Lee, Joon Kim

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalFEBS Letters
Volume560
Issue number1-3
DOIs
Publication statusPublished - 2004 Feb 27

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Keywords

  • Apoptosis
  • Cytokine
  • DNA repair
  • Lymphocyte
  • rpS3

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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