RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer

Bo Ram Kim, Myoung Hee Kang, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Sun Il Lee, Sanghee Kang, Sung Yup Joung, Suk Young Lee, Dae Hee Lee, Byung Wook Min, Sang Cheul Oh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent studies have determined that inactivation of runt-related transcription factor 3 (RUNX3) expression is highly associated with lymph node metastasis and poor prognosis in various types of cancer. However, the mechanism of RUNX3-mediated suppression of tumor metastasis remains unclear. Herein, we aimed to clarify the effect of RUNX3 on metastasis and angiogenesis in colorectal cancer (CRC). Firstly, we found that the reduction in expression of RUNX3 in CRC tissues when compared with tumor adjacent normal colon tissues, as indicated by reduced RUNX3 staining, was significantly correlated with tumor-node-metastasis (TNM) stage. Secondly, we demonstrated that RUNX3 overexpression inhibited CRC cell migration and invasion resulting from the upregulation of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. In contrast, the knockdown of RUNX3 reduced the inhibition of migration and invasion of CRC cells. Finally, we found that restoration of RUNX3 decreased vascular endothelial growth factor (VEGF) secretion and suppressed endothelial cell growth and tube formation in CRC cells. All in all, our findings may provide insight into the development of RUNX3 for CRC metastasis diagnostics and therapeutics.

Original languageEnglish
Pages (from-to)2601-2608
Number of pages8
JournalOncology Reports
Volume36
Issue number5
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • Angiogenesis
  • Colorectal cancer
  • Migration
  • Runt-related transcription factor 3
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer'. Together they form a unique fingerprint.

  • Cite this

    Kim, B. R., Kang, M. H., Kim, J. L., Na, Y. J., Park, S. H., Lee, S. I., Kang, S., Joung, S. Y., Lee, S. Y., Lee, D. H., Min, B. W., & Oh, S. C. (2016). RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer. Oncology Reports, 36(5), 2601-2608. https://doi.org/10.3892/or.2016.5086