Safety and efficacy of rice bran supercritical CO2 extract for hair growth in androgenic alopecia: A 16-week double-blind randomized controlled trial

Jae Suk Choi, Jae Beom Park, Woi Sook Moon, Jin Nam Moon, Sang Wook Son, Mi Ryung Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We conducted a 16-week double-blind randomized controlled single-center trial to evaluate the safety and efficacy of dermal rice bran supercritical CO2 extract (RB-SCE) in the treatment of androgenic alopecia. Fifty alopecia patients were randomly assigned to the experimental and placebo groups. The experimental group received a dermal application of 0.5% RB-SCE (8 mL/d) to the head skin for 16 weeks while the control group received a dermal application of placebo. Changes in hair count, diameter, and density were evaluated with a Folliscope®. Patient satisfaction was evaluated via questionnaire and clinical photographs were rated by dermatologists. The results showed that RB-SCE significantly increased hair density and hair diameter in male subjects. Patient satisfaction and the evaluation of photographs by dermatologists also confirmed the effectiveness of RB-SCE in the treatment of alopecia. No adverse reactions related to RB-SCE were reported. Therefore, RB-SCE shows promise for use in functional cosmetics and pharmaceuticals.

Original languageEnglish
Pages (from-to)1856-1863
Number of pages8
JournalBiological and Pharmaceutical Bulletin
Volume38
Issue number12
Publication statusPublished - 2015 Dec 1

Keywords

  • Alopecia
  • Clinical study
  • Hair growth-promoting activity
  • Rice bran supercritical CO extract

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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