SALM Synaptic Cell Adhesion-like Molecules Regulate the Differentiation of Excitatory Synapses

Jaewon Ko, Seho Kim, Hye Sun Chung, Karam Kim, Kihoon Han, Hyun Kim, Heejung Jun, Bong Kiun Kaang, Eunjoon Kim

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Synaptic cell adhesion molecules (CAMs) are known to play key roles in various aspects of synaptic structures and functions, including early differentiation, maintenance, and plasticity. We herein report the identification of a family of cell adhesion-like molecules termed SALM that interacts with the abundant postsynaptic density (PSD) protein PSD-95. SALM2, a SALM isoform, distributes to excitatory, but not inhibitory, synaptic sites. Overexpression of SALM2 increases the number of excitatory synapses and dendritic spines. Mislocalized expression of SALM2 disrupts excitatory synapses and dendritic spines. Bead-induced direct aggregation of SALM2 results in coclustering of PSD-95 and other postsynaptic proteins, including GKAP and AMPA receptors. Knockdown of SALM2 by RNA interference reduces the number of excitatory synapses and dendritic spines and the frequency, but not amplitude, of miniature excitatory postsynaptic currents. These results suggest that SALM2 is an important regulator of the differentiation of excitatory synapses.

Original languageEnglish
Pages (from-to)233-245
Number of pages13
JournalNeuron
Volume50
Issue number2
DOIs
Publication statusPublished - 2006 Apr 20

Keywords

  • CELLBIO
  • DEVBIO
  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

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