Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men: The 2008-2010 Korea National Health and Nutrition Examination Survey

S. J. Baek, G. E. Nam, K. D. Han, S. W. Choi, S. W. Jung, A. R. Bok, Yang-Hyun Kim, K. S. Lee, B. D. Han, Do-Hoon Kim

Research output: Contribution to journalArticle

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Abstract

Background: Recently, aging has been shown to be associated with sarcopenic obesity (SO), of which decreased muscle mass and increased fat mass are features. Sarcopenia and obesity alone are known to be associated with abnormal lipid metabolism. However, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone. Aim: We aimed to investigate the association between SO and dyslipidemia in elderly Koreans. Subjects and methods: This study was based on data collected during the 2008-2010 Korea National Health and Nutrition Examination Survey. We included 1,466 men and 2,017 women aged 65 years and over. Sarcopenia was indicated in participants with height- or weight-adjusted appendicular skeletal muscle that was 1 standard deviation below the sex-specific mean for the young reference group, and obesity was defined as a body mass index ≥25 kg/m2. Dyslipidemia was defined according to the National Cholesterol Education Program-Adult Treatment Panel III. Results: After adjusting for confounding factors, the SO group had a higher risk for dyslipidemia [odds ratio (OR) 2.82 (95% confidence interval 1.76-4.51)] than the obese group [2.12 (1.11-4.07)] and sarcopenic group [1.46 (1.01-2.11)] (p < 0.001) only in men. Furthermore, the SO group in men had the highest OR for hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, hyper-low-density lipoprotein cholesterolemia, and a high ratio of triglyceride to high-density lipoprotein cholesterol even after further adjustments. Conclusions: In Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone.

Original languageEnglish
Pages (from-to)247-260
Number of pages14
JournalJournal of Endocrinological Investigation
Volume37
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Sarcopenia
Nutrition Surveys
Korea
Dyslipidemias
Obesity
Paraphilic Disorders
Odds Ratio
Social Adjustment
Hypertriglyceridemia
HDL Lipoproteins
Hypercholesterolemia
LDL Lipoproteins
Lipid Metabolism
HDL Cholesterol
Skeletal Muscle
Triglycerides
Body Mass Index
Fats
Cholesterol
Confidence Intervals

Keywords

  • Dyslipidemia
  • Obesity
  • Sarcopenia
  • Sarcopenic obesity

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men : The 2008-2010 Korea National Health and Nutrition Examination Survey. / Baek, S. J.; Nam, G. E.; Han, K. D.; Choi, S. W.; Jung, S. W.; Bok, A. R.; Kim, Yang-Hyun; Lee, K. S.; Han, B. D.; Kim, Do-Hoon.

In: Journal of Endocrinological Investigation, Vol. 37, No. 3, 01.01.2014, p. 247-260.

Research output: Contribution to journalArticle

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abstract = "Background: Recently, aging has been shown to be associated with sarcopenic obesity (SO), of which decreased muscle mass and increased fat mass are features. Sarcopenia and obesity alone are known to be associated with abnormal lipid metabolism. However, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone. Aim: We aimed to investigate the association between SO and dyslipidemia in elderly Koreans. Subjects and methods: This study was based on data collected during the 2008-2010 Korea National Health and Nutrition Examination Survey. We included 1,466 men and 2,017 women aged 65 years and over. Sarcopenia was indicated in participants with height- or weight-adjusted appendicular skeletal muscle that was 1 standard deviation below the sex-specific mean for the young reference group, and obesity was defined as a body mass index ≥25 kg/m2. Dyslipidemia was defined according to the National Cholesterol Education Program-Adult Treatment Panel III. Results: After adjusting for confounding factors, the SO group had a higher risk for dyslipidemia [odds ratio (OR) 2.82 (95{\%} confidence interval 1.76-4.51)] than the obese group [2.12 (1.11-4.07)] and sarcopenic group [1.46 (1.01-2.11)] (p < 0.001) only in men. Furthermore, the SO group in men had the highest OR for hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, hyper-low-density lipoprotein cholesterolemia, and a high ratio of triglyceride to high-density lipoprotein cholesterol even after further adjustments. Conclusions: In Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone.",
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T1 - Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men

T2 - The 2008-2010 Korea National Health and Nutrition Examination Survey

AU - Baek, S. J.

AU - Nam, G. E.

AU - Han, K. D.

AU - Choi, S. W.

AU - Jung, S. W.

AU - Bok, A. R.

AU - Kim, Yang-Hyun

AU - Lee, K. S.

AU - Han, B. D.

AU - Kim, Do-Hoon

PY - 2014/1/1

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N2 - Background: Recently, aging has been shown to be associated with sarcopenic obesity (SO), of which decreased muscle mass and increased fat mass are features. Sarcopenia and obesity alone are known to be associated with abnormal lipid metabolism. However, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone. Aim: We aimed to investigate the association between SO and dyslipidemia in elderly Koreans. Subjects and methods: This study was based on data collected during the 2008-2010 Korea National Health and Nutrition Examination Survey. We included 1,466 men and 2,017 women aged 65 years and over. Sarcopenia was indicated in participants with height- or weight-adjusted appendicular skeletal muscle that was 1 standard deviation below the sex-specific mean for the young reference group, and obesity was defined as a body mass index ≥25 kg/m2. Dyslipidemia was defined according to the National Cholesterol Education Program-Adult Treatment Panel III. Results: After adjusting for confounding factors, the SO group had a higher risk for dyslipidemia [odds ratio (OR) 2.82 (95% confidence interval 1.76-4.51)] than the obese group [2.12 (1.11-4.07)] and sarcopenic group [1.46 (1.01-2.11)] (p < 0.001) only in men. Furthermore, the SO group in men had the highest OR for hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, hyper-low-density lipoprotein cholesterolemia, and a high ratio of triglyceride to high-density lipoprotein cholesterol even after further adjustments. Conclusions: In Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone.

AB - Background: Recently, aging has been shown to be associated with sarcopenic obesity (SO), of which decreased muscle mass and increased fat mass are features. Sarcopenia and obesity alone are known to be associated with abnormal lipid metabolism. However, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone. Aim: We aimed to investigate the association between SO and dyslipidemia in elderly Koreans. Subjects and methods: This study was based on data collected during the 2008-2010 Korea National Health and Nutrition Examination Survey. We included 1,466 men and 2,017 women aged 65 years and over. Sarcopenia was indicated in participants with height- or weight-adjusted appendicular skeletal muscle that was 1 standard deviation below the sex-specific mean for the young reference group, and obesity was defined as a body mass index ≥25 kg/m2. Dyslipidemia was defined according to the National Cholesterol Education Program-Adult Treatment Panel III. Results: After adjusting for confounding factors, the SO group had a higher risk for dyslipidemia [odds ratio (OR) 2.82 (95% confidence interval 1.76-4.51)] than the obese group [2.12 (1.11-4.07)] and sarcopenic group [1.46 (1.01-2.11)] (p < 0.001) only in men. Furthermore, the SO group in men had the highest OR for hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia, hyper-low-density lipoprotein cholesterolemia, and a high ratio of triglyceride to high-density lipoprotein cholesterol even after further adjustments. Conclusions: In Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone.

KW - Dyslipidemia

KW - Obesity

KW - Sarcopenia

KW - Sarcopenic obesity

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