SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways

Soo Jin Oh, Ok Sarah Shin

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.

Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalJournal of Microbiology
Volume60
Issue number3
DOIs
Publication statusPublished - 2022 Mar
Externally publishedYes

Keywords

  • COVID-19
  • SARS-CoV-2
  • immunity
  • interferon

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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