Scaffold-Based Therapies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

the International Consensus Group on Cartilage Repair of the Ankle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Scaffold-Based Therapies” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51% to 74%; strong consensus, 75% to 99%; unanimous, 100%. Results: A total of 9 statements on scaffold-based therapies reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. One achieved unanimous support, 8 reached strong consensus (greater than 75% agreement), and 1 was removed because of redundancy in the information provided. All statements reached at least 80% agreement. Conclusions: This international consensus derived from leaders in the field will assist clinicians with applying scaffold-based therapies as a treatment strategy for osteochondral lesions of the talus. Level of Evidence: Level V, expert opinion.

Original languageEnglish
Pages (from-to)41S-47S
JournalFoot and Ankle International
Volume39
Issue number1_suppl
DOIs
Publication statusPublished - 2018 Jul 1

Fingerprint

Ankle
Cartilage
Practice Guidelines
Therapeutics
Talus
Expert Testimony

Keywords

  • ACI
  • AMIC
  • ankle
  • MACI
  • osteochondral lesion
  • scaffold
  • talus

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Scaffold-Based Therapies : Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. / the International Consensus Group on Cartilage Repair of the Ankle.

In: Foot and Ankle International, Vol. 39, No. 1_suppl, 01.07.2018, p. 41S-47S.

Research output: Contribution to journalArticle

the International Consensus Group on Cartilage Repair of the Ankle. / Scaffold-Based Therapies : Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. In: Foot and Ankle International. 2018 ; Vol. 39, No. 1_suppl. pp. 41S-47S.
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title = "Scaffold-Based Therapies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle",
abstract = "Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Scaffold-Based Therapies” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51{\%} to 74{\%}; strong consensus, 75{\%} to 99{\%}; unanimous, 100{\%}. Results: A total of 9 statements on scaffold-based therapies reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. One achieved unanimous support, 8 reached strong consensus (greater than 75{\%} agreement), and 1 was removed because of redundancy in the information provided. All statements reached at least 80{\%} agreement. Conclusions: This international consensus derived from leaders in the field will assist clinicians with applying scaffold-based therapies as a treatment strategy for osteochondral lesions of the talus. Level of Evidence: Level V, expert opinion.",
keywords = "ACI, AMIC, ankle, MACI, osteochondral lesion, scaffold, talus",
author = "{the International Consensus Group on Cartilage Repair of the Ankle} and Rothrauff, {Benjamin B.} and Murawski, {Christopher D.} and Chayanin Angthong and Christoph Becher and Stefan Nehrer and Philipp Niemeyer and Martin Sullivan and Victor Valderrabano and Markus Walther and Ferkel, {Richard D.} and Jakob Ackermann and Adams, {Samuel B.} and Andrews, {Carol L.} and Batista, {Jorge P.} and Baur, {Onno L.} and Steve Bayer and Berlet, {Gregory C.} and Boakye, {Lorraine A.T.} and Brown, {Alexandra J.} and Roberto Buda and Calder, {James D.F.} and Canata, {Gian Luigi} and Carreira, {Dominic S.} and Clanton, {Thomas O.} and Jari Dahmen and Pieter D’Hooghe and DiGiovanni, {Christopher W.} and Dombrowski, {Malcolm E.} and Drakos, {Mark C.} and Ferrao, {Paulo N.F.} and Fortier, {Lisa A.} and Mark Glazebrook and Eric Giza and Mohamed Gomaa and Simon G{\"o}rtz and Haleem, {Amgad M.} and Kamran Hamid and Laszlo Hangody and Hannon, {Charles P.} and Daniel Haverkamp and Jay Hertel and Beat Hintermann and Hogan, {Ma Calus V.} and Hunt, {Kenneth J.} and Hurley, {Eoghan T.} and J{\'o}n Karlsson and Kearns, {Stephen R.} and Kennedy, {John G.} and Kerkhoffs, {Gino M.M.J.} and Kim, {Hak Jun}",
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T1 - Scaffold-Based Therapies

T2 - Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

AU - the International Consensus Group on Cartilage Repair of the Ankle

AU - Rothrauff, Benjamin B.

AU - Murawski, Christopher D.

AU - Angthong, Chayanin

AU - Becher, Christoph

AU - Nehrer, Stefan

AU - Niemeyer, Philipp

AU - Sullivan, Martin

AU - Valderrabano, Victor

AU - Walther, Markus

AU - Ferkel, Richard D.

AU - Ackermann, Jakob

AU - Adams, Samuel B.

AU - Andrews, Carol L.

AU - Batista, Jorge P.

AU - Baur, Onno L.

AU - Bayer, Steve

AU - Berlet, Gregory C.

AU - Boakye, Lorraine A.T.

AU - Brown, Alexandra J.

AU - Buda, Roberto

AU - Calder, James D.F.

AU - Canata, Gian Luigi

AU - Carreira, Dominic S.

AU - Clanton, Thomas O.

AU - Dahmen, Jari

AU - D’Hooghe, Pieter

AU - DiGiovanni, Christopher W.

AU - Dombrowski, Malcolm E.

AU - Drakos, Mark C.

AU - Ferrao, Paulo N.F.

AU - Fortier, Lisa A.

AU - Glazebrook, Mark

AU - Giza, Eric

AU - Gomaa, Mohamed

AU - Görtz, Simon

AU - Haleem, Amgad M.

AU - Hamid, Kamran

AU - Hangody, Laszlo

AU - Hannon, Charles P.

AU - Haverkamp, Daniel

AU - Hertel, Jay

AU - Hintermann, Beat

AU - Hogan, Ma Calus V.

AU - Hunt, Kenneth J.

AU - Hurley, Eoghan T.

AU - Karlsson, Jón

AU - Kearns, Stephen R.

AU - Kennedy, John G.

AU - Kerkhoffs, Gino M.M.J.

AU - Kim, Hak Jun

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Scaffold-Based Therapies” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51% to 74%; strong consensus, 75% to 99%; unanimous, 100%. Results: A total of 9 statements on scaffold-based therapies reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. One achieved unanimous support, 8 reached strong consensus (greater than 75% agreement), and 1 was removed because of redundancy in the information provided. All statements reached at least 80% agreement. Conclusions: This international consensus derived from leaders in the field will assist clinicians with applying scaffold-based therapies as a treatment strategy for osteochondral lesions of the talus. Level of Evidence: Level V, expert opinion.

AB - Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on “Scaffold-Based Therapies” developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. Methods: Seventy-five international experts in cartilage repair of the ankle representing 25 countries and 1 territory were convened and participated in a process based on the Delphi method of achieving consensus. Questions and statements were drafted within 11 working groups focusing on specific topics within cartilage repair of the ankle, after which a comprehensive literature review was performed and the available evidence for each statement was graded. Discussion and debate occurred in cases where statements were not agreed upon in unanimous fashion within the working groups. A final vote was then held, and the strength of consensus was characterized as follows: consensus, 51% to 74%; strong consensus, 75% to 99%; unanimous, 100%. Results: A total of 9 statements on scaffold-based therapies reached consensus during the 2017 International Consensus Meeting on Cartilage Repair of the Ankle. One achieved unanimous support, 8 reached strong consensus (greater than 75% agreement), and 1 was removed because of redundancy in the information provided. All statements reached at least 80% agreement. Conclusions: This international consensus derived from leaders in the field will assist clinicians with applying scaffold-based therapies as a treatment strategy for osteochondral lesions of the talus. Level of Evidence: Level V, expert opinion.

KW - ACI

KW - AMIC

KW - ankle

KW - MACI

KW - osteochondral lesion

KW - scaffold

KW - talus

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