Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

Gerald Stöber, Dorit Ben-Shachar, M. Cardon, Peter Falkai, Alfred N. Fonteh, Micha Gawlik, Birte Y. Glenthoj, Edna Grnblatt, Assen Jablensky, Yong Ku Kim, Johannes Kornhuber, Thomas F. McNeil, Norbert Müller, Bob Oranje, Toshikazu Saito, Mohamed Saoud, Andrea Schmitt, Michal Schwartz, Johannes Thome, Marat UzbekovNuria Durany, Peter Riederer

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

Original languageEnglish
Pages (from-to)127-155
Number of pages29
JournalWorld Journal of Biological Psychiatry
Volume10
Issue number2
DOIs
Publication statusPublished - 2009 Nov 30

Fingerprint

Advisory Committees
Schizophrenia
Consensus
Biomarkers
Brain
Aptitude
Genetic Markers
Psychotic Disorders
Psychiatry
Central Nervous System
Pathology
Technology
Phenotype
Research

Keywords

  • Biological markers
  • Review
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Schizophrenia : From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. / Stöber, Gerald; Ben-Shachar, Dorit; Cardon, M.; Falkai, Peter; Fonteh, Alfred N.; Gawlik, Micha; Glenthoj, Birte Y.; Grnblatt, Edna; Jablensky, Assen; Kim, Yong Ku; Kornhuber, Johannes; McNeil, Thomas F.; Müller, Norbert; Oranje, Bob; Saito, Toshikazu; Saoud, Mohamed; Schmitt, Andrea; Schwartz, Michal; Thome, Johannes; Uzbekov, Marat; Durany, Nuria; Riederer, Peter.

In: World Journal of Biological Psychiatry, Vol. 10, No. 2, 30.11.2009, p. 127-155.

Research output: Contribution to journalArticle

Stöber, G, Ben-Shachar, D, Cardon, M, Falkai, P, Fonteh, AN, Gawlik, M, Glenthoj, BY, Grnblatt, E, Jablensky, A, Kim, YK, Kornhuber, J, McNeil, TF, Müller, N, Oranje, B, Saito, T, Saoud, M, Schmitt, A, Schwartz, M, Thome, J, Uzbekov, M, Durany, N & Riederer, P 2009, 'Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers', World Journal of Biological Psychiatry, vol. 10, no. 2, pp. 127-155. https://doi.org/10.1080/15622970902898980
Stöber, Gerald ; Ben-Shachar, Dorit ; Cardon, M. ; Falkai, Peter ; Fonteh, Alfred N. ; Gawlik, Micha ; Glenthoj, Birte Y. ; Grnblatt, Edna ; Jablensky, Assen ; Kim, Yong Ku ; Kornhuber, Johannes ; McNeil, Thomas F. ; Müller, Norbert ; Oranje, Bob ; Saito, Toshikazu ; Saoud, Mohamed ; Schmitt, Andrea ; Schwartz, Michal ; Thome, Johannes ; Uzbekov, Marat ; Durany, Nuria ; Riederer, Peter. / Schizophrenia : From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. In: World Journal of Biological Psychiatry. 2009 ; Vol. 10, No. 2. pp. 127-155.
@article{cac96110c6da45faaa28ff1de22924f3,
title = "Schizophrenia: From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers",
abstract = "Objective. The phenotypic complexity, together with the multifarious nature of the so-called {"}schizophrenic psychoses{"}, limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.",
keywords = "Biological markers, Review, Schizophrenia",
author = "Gerald St{\"o}ber and Dorit Ben-Shachar and M. Cardon and Peter Falkai and Fonteh, {Alfred N.} and Micha Gawlik and Glenthoj, {Birte Y.} and Edna Grnblatt and Assen Jablensky and Kim, {Yong Ku} and Johannes Kornhuber and McNeil, {Thomas F.} and Norbert M{\"u}ller and Bob Oranje and Toshikazu Saito and Mohamed Saoud and Andrea Schmitt and Michal Schwartz and Johannes Thome and Marat Uzbekov and Nuria Durany and Peter Riederer",
year = "2009",
month = "11",
day = "30",
doi = "10.1080/15622970902898980",
language = "English",
volume = "10",
pages = "127--155",
journal = "World Journal of Biological Psychiatry",
issn = "1562-2975",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Schizophrenia

T2 - From the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

AU - Stöber, Gerald

AU - Ben-Shachar, Dorit

AU - Cardon, M.

AU - Falkai, Peter

AU - Fonteh, Alfred N.

AU - Gawlik, Micha

AU - Glenthoj, Birte Y.

AU - Grnblatt, Edna

AU - Jablensky, Assen

AU - Kim, Yong Ku

AU - Kornhuber, Johannes

AU - McNeil, Thomas F.

AU - Müller, Norbert

AU - Oranje, Bob

AU - Saito, Toshikazu

AU - Saoud, Mohamed

AU - Schmitt, Andrea

AU - Schwartz, Michal

AU - Thome, Johannes

AU - Uzbekov, Marat

AU - Durany, Nuria

AU - Riederer, Peter

PY - 2009/11/30

Y1 - 2009/11/30

N2 - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

AB - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

KW - Biological markers

KW - Review

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=67650156832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650156832&partnerID=8YFLogxK

U2 - 10.1080/15622970902898980

DO - 10.1080/15622970902898980

M3 - Article

C2 - 19396704

AN - SCOPUS:67650156832

VL - 10

SP - 127

EP - 155

JO - World Journal of Biological Psychiatry

JF - World Journal of Biological Psychiatry

SN - 1562-2975

IS - 2

ER -