Schweinfurthins A-Q: Isolation, synthesis, and biochemical properties

Dipesh S. Harmalkar, Jyotirling R. Mali, Aneesh Sivaraman, Yongseok Choi, Kyeong Lee

Research output: Contribution to journalReview article

Abstract

Stilbene analogues have shown remarkable structural diversity constituting simple or tangled structures, which have attracted the synthetic as well as the medicinal chemistry communities. Schweinfurthins are a family of prenylated/geranylated/farnesylated stilbenes that are isolated from an African plant belonging to the Macaranga species. These compounds have displayed potency towards central nervous system, renal and breast cancer cell lines. Specifically, these compounds have been found to be potent and selective inhibitors of cell growth in the National Cancer Institute's 60 cell-line screen. In this review article, we described the isolation, synthesis, and biochemical properties of schweinfurthins.

Original languageEnglish
Pages (from-to)21191-21209
Number of pages19
JournalRSC Advances
Volume8
Issue number38
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Harmalkar, D. S., Mali, J. R., Sivaraman, A., Choi, Y., & Lee, K. (2018). Schweinfurthins A-Q: Isolation, synthesis, and biochemical properties. RSC Advances, 8(38), 21191-21209. https://doi.org/10.1039/c8ra02872a