Scn2a haploinsufficiency in mice suppresses hippocampal neuronal excitability, excitatory synaptic drive, and long-term potentiation, and spatial learning and memory

Wangyong Shin, Hanseul Kweon, Ryeonghwa Kang, Doyoun Kim, Kyungdeok Kim, Muwon Kang, Seo Yeong Kim, Sun Nam Hwang, Jin Yong Kim, Esther Yang, Hyun Kim, Eunjoon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nav1.2, a voltage-gated sodium channel subunit encoded by the Scn2a gene, has been implicated in various brain disorders, including epilepsy, autism spectrum disorder, intellectual disability, and schizophrenia. Nav1.2 is known to regulate the generation of action potentials in the axon initial segment and their propagation along axonal pathways. Nav1.2 also regulates synaptic integration and plasticity by promoting back-propagation of action potentials to dendrites, but whether Nav1.2 deletion in mice affects neuronal excitability, synaptic transmission, synaptic plasticity, and/or disease-related animal behaviors remains largely unclear. Here, we report that mice heterozygous for the Scn2a gene (Scn2a+/- mice) show decreased neuronal excitability and suppressed excitatory synaptic transmission in the presence of network activity in the hippocampus. In addition, Scn2a+/- mice show suppressed hippocampal long-term potentiation (LTP) in association with impaired spatial learning and memory, but show largely normal locomotor activity, anxiety-like behavior, social interaction, repetitive behavior, and whole-brain excitation. These results suggest that Nav1.2 regulates hippocampal neuronal excitability, excitatory synaptic drive, LTP, and spatial learning and memory in mice.

Original languageEnglish
Article number145
JournalFrontiers in Molecular Neuroscience
Volume12
DOIs
Publication statusPublished - 2019 May 27

Fingerprint

Haploinsufficiency
Long-Term Potentiation
Neuronal Plasticity
NAV1.2 Voltage-Gated Sodium Channel
Synaptic Transmission
Action Potentials
Brain Diseases
Locomotion
Interpersonal Relations
Dendrites
Intellectual Disability
Genes
Epilepsy
Hippocampus
Schizophrenia
Anxiety
Spatial Memory
Drive
Spatial Learning
Brain

Keywords

  • Autism
  • Intellectual disability
  • Learning and memory
  • Neuronal excitability
  • Schizophrenia
  • Sodium channel
  • Synaptic plasticity
  • Synaptic transmission

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Scn2a haploinsufficiency in mice suppresses hippocampal neuronal excitability, excitatory synaptic drive, and long-term potentiation, and spatial learning and memory. / Shin, Wangyong; Kweon, Hanseul; Kang, Ryeonghwa; Kim, Doyoun; Kim, Kyungdeok; Kang, Muwon; Kim, Seo Yeong; Hwang, Sun Nam; Kim, Jin Yong; Yang, Esther; Kim, Hyun; Kim, Eunjoon.

In: Frontiers in Molecular Neuroscience, Vol. 12, 145, 27.05.2019.

Research output: Contribution to journalArticle

Shin, Wangyong ; Kweon, Hanseul ; Kang, Ryeonghwa ; Kim, Doyoun ; Kim, Kyungdeok ; Kang, Muwon ; Kim, Seo Yeong ; Hwang, Sun Nam ; Kim, Jin Yong ; Yang, Esther ; Kim, Hyun ; Kim, Eunjoon. / Scn2a haploinsufficiency in mice suppresses hippocampal neuronal excitability, excitatory synaptic drive, and long-term potentiation, and spatial learning and memory. In: Frontiers in Molecular Neuroscience. 2019 ; Vol. 12.
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