Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism

Heon-Jeong Lee, Seung M. Sung, Se W. Lim, Jong W. Paik, Kim Leen Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) - 1438 A/G polymorphism and seasonal variation in a young Korean healthy population. Methods: 297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A - 1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ). Results: The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A - 1438 A allele compared with non-seasonals (χ2 = 6.80, p = 0.009; OR = 1.79; 95% CI, 1.15-2.78). Conclusion: These results suggest that the 5HTR2A - 1438 A/G polymorphism is possibly related to seasonality in the Korean population.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Affective Disorders
Volume95
Issue number1-3
DOIs
Publication statusPublished - 2006 Oct 1

Fingerprint

Receptor, Serotonin, 5-HT2A
Genotype
Seasonal Affective Disorder
Medical Students
Population
Alleles
Surveys and Questionnaires

Keywords

  • Association
  • Seasonal affective disorder
  • Seasonality
  • Serotonin 2A receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism. / Lee, Heon-Jeong; Sung, Seung M.; Lim, Se W.; Paik, Jong W.; Leen Kim, Kim.

In: Journal of Affective Disorders, Vol. 95, No. 1-3, 01.10.2006, p. 145-148.

Research output: Contribution to journalArticle

Lee, Heon-Jeong ; Sung, Seung M. ; Lim, Se W. ; Paik, Jong W. ; Leen Kim, Kim. / Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism. In: Journal of Affective Disorders. 2006 ; Vol. 95, No. 1-3. pp. 145-148.
@article{c4e2e5a2465a4ce1a0a36a52134cba1d,
title = "Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism",
abstract = "Background: Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) - 1438 A/G polymorphism and seasonal variation in a young Korean healthy population. Methods: 297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A - 1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ). Results: The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A - 1438 A allele compared with non-seasonals (χ2 = 6.80, p = 0.009; OR = 1.79; 95{\%} CI, 1.15-2.78). Conclusion: These results suggest that the 5HTR2A - 1438 A/G polymorphism is possibly related to seasonality in the Korean population.",
keywords = "Association, Seasonal affective disorder, Seasonality, Serotonin 2A receptor",
author = "Heon-Jeong Lee and Sung, {Seung M.} and Lim, {Se W.} and Paik, {Jong W.} and {Leen Kim}, Kim",
year = "2006",
month = "10",
day = "1",
doi = "10.1016/j.jad.2006.05.001",
language = "English",
volume = "95",
pages = "145--148",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Seasonality associated with the serotonin 2A receptor - 1438 A/G polymorphism

AU - Lee, Heon-Jeong

AU - Sung, Seung M.

AU - Lim, Se W.

AU - Paik, Jong W.

AU - Leen Kim, Kim

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Background: Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) - 1438 A/G polymorphism and seasonal variation in a young Korean healthy population. Methods: 297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A - 1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ). Results: The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A - 1438 A allele compared with non-seasonals (χ2 = 6.80, p = 0.009; OR = 1.79; 95% CI, 1.15-2.78). Conclusion: These results suggest that the 5HTR2A - 1438 A/G polymorphism is possibly related to seasonality in the Korean population.

AB - Background: Seasonal affective disorder and seasonal rhythms in mood and behavior (seasonality) have been reported to be associated with serotonergic system. In this study we investigated the relationship between the serotonin 2A receptor (5HTR2A) - 1438 A/G polymorphism and seasonal variation in a young Korean healthy population. Methods: 297 young Korean medical students were recruited for this study. They were genotyped for the 5HTR2A - 1438 A/G polymorphism and evaluated the seasonal variation in mood and behavior by the Seasonality Pattern Assessment Questionnaire (SPAQ). Results: The Global Seasonality Score of the SPAQ among three genotypes were not different. However, the comparison between seasonals and non-seasonals showed significant difference in the genotype distribution. The winter-type seasonals showed a significantly higher frequency of the 5HTR2A - 1438 A allele compared with non-seasonals (χ2 = 6.80, p = 0.009; OR = 1.79; 95% CI, 1.15-2.78). Conclusion: These results suggest that the 5HTR2A - 1438 A/G polymorphism is possibly related to seasonality in the Korean population.

KW - Association

KW - Seasonal affective disorder

KW - Seasonality

KW - Serotonin 2A receptor

UR - http://www.scopus.com/inward/record.url?scp=33846188599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846188599&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2006.05.001

DO - 10.1016/j.jad.2006.05.001

M3 - Article

C2 - 16762419

AN - SCOPUS:33846188599

VL - 95

SP - 145

EP - 148

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -