Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma

J. J. Lee, H. J. Kim, I. J. Chung, M. R. Park, D. W. Ryang, Chul Won Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 56-year-old woman was treated with combination chemotherapy and radiation therapy for peripheral T-cell lymphoma. Following complete remission for a period of 6 months, she returned again with marked leukocytosis. Leukemic cells were characterized by scanty cytoplasm with fine azurophilic granules, and were highly positive for myeloperoxidase and sudan black-B. Immunophenotypic analysis revealed that blast cells were positive for myeloid antigens (CD13, CD33), and natural killer (NK) cell antigen (CD56), but negative for T-cell antigens (CD2, CD5, CD7), B-cell antigens (CD19, CD20), CD34, and HLA-DR. The case was diagnosed as secondary myeloid/NK cell acute leukemia following non-Hodgkin's lymphoma. Despite aggressive chemotherapy against leukemia, she died of multiorgan failure 7 months following onset of leukemia. We present, to the best of our knowledge, the first published report of what seems to be a secondary myeloid/NK cell acute leukemia following T-cell lymphoma.

Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalLeukemia and Lymphoma
Volume41
Issue number3-4
Publication statusPublished - 2001 Jun 13
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Natural Killer Cells
Leukemia
CD56 Antigens
Sialic Acid Binding Ig-like Lectin 3
CD19 Antigens
Peripheral T-Cell Lymphoma
CD13 Antigens
Viral Tumor Antigens
Leukocytosis
HLA-DR Antigens
Combination Drug Therapy
Non-Hodgkin's Lymphoma
Peroxidase
Cytoplasm
Radiotherapy
T-Lymphocytes
Drug Therapy

Keywords

  • Secondary myeloid/NK cell acute leukemia
  • T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Lee, J. J., Kim, H. J., Chung, I. J., Park, M. R., Ryang, D. W., & Choi, C. W. (2001). Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. Leukemia and Lymphoma, 41(3-4), 457-460.

Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. / Lee, J. J.; Kim, H. J.; Chung, I. J.; Park, M. R.; Ryang, D. W.; Choi, Chul Won.

In: Leukemia and Lymphoma, Vol. 41, No. 3-4, 13.06.2001, p. 457-460.

Research output: Contribution to journalArticle

Lee, JJ, Kim, HJ, Chung, IJ, Park, MR, Ryang, DW & Choi, CW 2001, 'Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma', Leukemia and Lymphoma, vol. 41, no. 3-4, pp. 457-460.
Lee JJ, Kim HJ, Chung IJ, Park MR, Ryang DW, Choi CW. Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. Leukemia and Lymphoma. 2001 Jun 13;41(3-4):457-460.
Lee, J. J. ; Kim, H. J. ; Chung, I. J. ; Park, M. R. ; Ryang, D. W. ; Choi, Chul Won. / Secondary myeloid/natural killer cell acute leukemia following T-cell lymphoma. In: Leukemia and Lymphoma. 2001 ; Vol. 41, No. 3-4. pp. 457-460.
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