Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk

Nana Keum, Yin Cao, Hannah Oh, Stephanie A. Smith-Warner, John Orav, Kana Wu, Charles S. Fuchs, Eunyoung Cho, Edward L. Giovannucci

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A recent meta-analysis found that sedentary behaviors are associated with an increased colorectal cancer (CRC) risk. Yet, the finding on TV viewing time, the most widely used surrogate of sedentary behaviors, was based on only two studies. Furthermore, light-intensity activities (e.g., standing and slow walking), non-sedentary by posture but close to sedentary behaviors by Metabolic Equivalent Task values, have not been investigated in relation to CRC risk. Thus, we prospectively analyzed the relationships based on 69,715 women from Nurses' Health Study (1992-2010) and 36,806 men from Health Professionals Follow-Up Study (1988 - 2010). Throughout follow-up, time spent on sedentary behaviors including sitting watching TV and on light-intensity activities were assessed repeatedly; incidence of CRC was ascertained. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models from each cohort. A total of 1,119 and 913 incident cases were documented from women and men, respectively. The multivariable HR comparing ≥ 21 versus < 7 hr/week of sitting watching TV was 1.21 (95% CI = 1.02 to 1.43, p trend =.01) in women and 1.06 (95% CI = 0.84 to 1.34, p trend =.93) in men. In women, those highly sedentary and physically less active had an approximately 41% elevated risk of CRC (95% CI = 1.03 to 1.92) compared with those less sedentary and physically more active. The other sedentary behaviors and light-intensity activities were not related to CRC risk in women or men. In conclusion, we found that prolonged sitting time watching TV was associated with an increased CRC risk in women but not in men.

Original languageEnglish
Pages (from-to)2109-2117
Number of pages9
JournalInternational Journal of Cancer
Volume138
Issue number9
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Light
Confidence Intervals
Metabolic Equivalent
Men's Health
Women's Health
Posture
Proportional Hazards Models
Walking
Meta-Analysis
Nurses
Incidence

Keywords

  • colorectal cancer
  • epidemiology
  • light-intensity activities
  • sedentary behaviors
  • sitting
  • TV watching

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Keum, N., Cao, Y., Oh, H., Smith-Warner, S. A., Orav, J., Wu, K., ... Giovannucci, E. L. (2016). Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk. International Journal of Cancer, 138(9), 2109-2117. https://doi.org/10.1002/ijc.29953

Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk. / Keum, Nana; Cao, Yin; Oh, Hannah; Smith-Warner, Stephanie A.; Orav, John; Wu, Kana; Fuchs, Charles S.; Cho, Eunyoung; Giovannucci, Edward L.

In: International Journal of Cancer, Vol. 138, No. 9, 01.05.2016, p. 2109-2117.

Research output: Contribution to journalArticle

Keum, N, Cao, Y, Oh, H, Smith-Warner, SA, Orav, J, Wu, K, Fuchs, CS, Cho, E & Giovannucci, EL 2016, 'Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk', International Journal of Cancer, vol. 138, no. 9, pp. 2109-2117. https://doi.org/10.1002/ijc.29953
Keum, Nana ; Cao, Yin ; Oh, Hannah ; Smith-Warner, Stephanie A. ; Orav, John ; Wu, Kana ; Fuchs, Charles S. ; Cho, Eunyoung ; Giovannucci, Edward L. / Sedentary behaviors and light-intensity activities in relation to colorectal cancer risk. In: International Journal of Cancer. 2016 ; Vol. 138, No. 9. pp. 2109-2117.
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