Selective colorimetric urine glucose detection by paper sensor functionalized with polyaniline nanoparticles and cell membrane

Taeha Lee, Insu Kim, Da Yeon Cheong, Seokbeom Roh, Hyo Gi Jung, Sang Won Lee, Hyun Soo Kim, Dae Sung Yoon, Yoochan Hong, Gyudo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

For the diabetes diagnosis, noninvasive methods are preferred to invasive methods; urine glucose measurement is an example of a noninvasive method. However, conventional noninvasive methods for urine glucose measurement are not intuitive. Furthermore, such methods exhibit low selectivity because they can detect interfering molecules in addition to glucose. Herein, we fabricate a noninvasive, intuitive, and highly selective paper sensor consisting of polyaniline nanoparticles (PAni-NPs) and red blood cell membranes (RBCMs). The PAni-NPs (adsorbed on the paper) are highly sensitive to hydrogen ions and change color from emeraldine blue to emeraldine green within a few seconds. The RBCM (coated on the PAni-NP-adsorbed paper) having the glucose transporter-1 protein plays the role of a smart filter that transports glucose but rejects other interfering molecules. In particular, the selectivity of the RBCM-coated PAni-NP-based paper sensor was approximately improved ∼85%, compared to the uncoated paper sensors. The paper sensor could detect urine glucose over the range of 0–10 mg/mL (0–56 mM), with a limit of detection of 0.54 mM. The proposed paper sensor will facilitate the development of a highly selective and colorimetric urine glucose monitoring system.

Original languageEnglish
Article number338387
JournalAnalytica Chimica Acta
Volume1158
DOIs
Publication statusPublished - 2021 May 8

Keywords

  • Colorimetric paper sensor
  • High selectivity
  • Noninvasive
  • Polyaniline nanoparticles
  • Red blood cell membrane
  • Urine glucose

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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