Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO2 nanofibers functionalized with reduced graphene oxide nanosheets

Seon Jin Choi, Bong Hoon Jang, Seo Jin Lee, Byoung Koun Min, Avner Rothschild, Il Doo Kim

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Sensitive detection of acetone and hydrogen sulfide levels in exhaled human breath, serving as breath markers for some diseases such as diabetes and halitosis, may offer useful information for early diagnosis of these diseases. Exhaled breath analyzers using semiconductor metal oxide (SMO) gas sensors have attracted much attention because they offer low cost fabrication, miniaturization, and integration into portable devices for noninvasive medical diagnosis. However, SMO gas sensors often display cross sensitivity to interfering species. Therefore, selective real-time detection of specific disease markers is a major challenge that must be overcome to ensure reliable breath analysis. In this work, we report on highly sensitive and selective acetone and hydrogen sulfide detection achieved by sensitizing electrospun SnO2 nanofibers with reduced graphene oxide (RGO) nanosheets. SnO2 nanofibers mixed with a small amount (0.01 wt %) of RGO nanosheets exhibited sensitive response to hydrogen sulfide (R air/Rgas = 34 at 5 ppm) at 200 C, whereas sensitive acetone detection (Rair/Rgas = 10 at 5 ppm) was achieved by increasing the RGO loading to 5 wt % and raising the operation temperature to 350 C. The detection limit of these sensors is predicted to be as low as 1 ppm for hydrogen sulfide and 100 ppb for acetone, respectively. These concentrations are much lower than in the exhaled breath of healthy people. This demonstrates that optimization of the RGO loading and the operation temperature of RGO-SnO2 nanocomposite gas sensors enables highly sensitive and selective detection of breath markers for the diagnosis of diabetes and halitosis.

Original languageEnglish
Pages (from-to)2588-2597
Number of pages10
JournalACS Applied Materials and Interfaces
Volume6
Issue number4
DOIs
Publication statusPublished - 2014 Feb 26

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Hydrogen Sulfide
Graphite
Nanosheets
Hydrogen sulfide
Medical problems
Nanofibers
Acetone
Oxides
Graphene
Chemical sensors
Metals
Semiconductor materials
Nanocomposites
Fabrication
Temperature
Sensors
Air

Keywords

  • electrospinning
  • exhaled breath analysis
  • gas sensors
  • reduced graphene oxide
  • SnO nanofibers

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO2 nanofibers functionalized with reduced graphene oxide nanosheets. / Choi, Seon Jin; Jang, Bong Hoon; Lee, Seo Jin; Min, Byoung Koun; Rothschild, Avner; Kim, Il Doo.

In: ACS Applied Materials and Interfaces, Vol. 6, No. 4, 26.02.2014, p. 2588-2597.

Research output: Contribution to journalArticle

Choi, Seon Jin ; Jang, Bong Hoon ; Lee, Seo Jin ; Min, Byoung Koun ; Rothschild, Avner ; Kim, Il Doo. / Selective detection of acetone and hydrogen sulfide for the diagnosis of diabetes and halitosis using SnO2 nanofibers functionalized with reduced graphene oxide nanosheets. In: ACS Applied Materials and Interfaces. 2014 ; Vol. 6, No. 4. pp. 2588-2597.
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