Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle - Cell Wall Binding Domain Conjugates

Domyoung Kim, Seok Joon Kwon, Xia Wu, Jessica Sauve, Inseon Lee, Jahyun Nam, Jungbae Kim, Jonathan S. Dordick

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Broad-spectrum antibiotics indiscriminately kill bacteria, removing nonpathogenic microorganisms and leading to evolution of antibiotic resistant strains. Specific antimicrobials that could selectively kill pathogenic bacteria without targeting other bacteria in the natural microbial community or microbiome may be able to address this concern. In this work, we demonstrate that silver nanoparticles, suitably conjugated to a selective cell wall binding domain (CBD), can efficiently target and selectively kill bacteria. As a relevant example, CBDBA from Bacillus anthracis selectively bound to B. anthracis in a mixture with Bacillus subtilis, as well in a mixture with Staphylococcus aureus. This new biologically-assisted hybrid strategy, therefore, has the potential to provide selective decontamination of pathogenic bacteria with minimal impact on normal microflora.

Original languageEnglish
Pages (from-to)13317-13324
Number of pages8
JournalACS Applied Materials and Interfaces
Volume10
Issue number16
DOIs
Publication statusPublished - 2018 Apr 25

Keywords

  • Bacillus anthracis
  • bactericidal activity
  • cell-wall binding domain
  • silver binding peptide
  • silver nanoparticles
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Materials Science(all)

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