Abstract
Chemotherapy-induced mucositis is mediated by the release of proinflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including the protection of membrane lipids and macromolecules against oxidative damage. However, to date, there is little evidence on the effect of trace elements on intestinal mucositis after chemotherapy. This study investigated the protective effect of selenium against chemotherapy-induced mucositis in rats. Twenty-four 9-wk-old female Wistar rats were randomized to 4 groups: control, selenium, 5-fluorouracil (5-FU), and 5-FU plus selenium. Mucositis was induced by a single dose of 5-FU (400 mg/kg BW) via intraperitoneal injection, and selenium was administered by a single intraperitoneal dose of sodium selenite (0.2 mg/kg BW). Diarrhea and weight loss after 5-FU administration were attenuated by selenium treatment. The mean villus height in the 5-FU plus selenium group was significantly taller than rats administered with 5-FU alone, but not significantly different compared to the control group. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1β, P < 0.01; TNF-α, P < 0.05). These findings indicate that selenium protects the mucosa during chemotherapy via its anti-inflammatory effects and its suppression of cytotoxic cytokine production.
| Original language | English |
|---|---|
| Pages (from-to) | 616-622 |
| Number of pages | 7 |
| Journal | Nutrition and Cancer |
| Volume | 69 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2017 May 19 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Oncology
- Nutrition and Dietetics
- Cancer Research
Cite this
Selenium Administration Attenuates 5-Flurouracil-Induced Intestinal Mucositis. / Lee, Jae Min; Chun, Hoon-Jai; Choi, Hyuk Soon; Kim, Eun-Sun; Seo, Yeon Seok; Jeen, Yoon Tae; Lee, Hong Sik; Um, Soon-Ho; Kim, Chul Hwan; Sul, Dong Geun.
In: Nutrition and Cancer, Vol. 69, No. 4, 19.05.2017, p. 616-622.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selenium Administration Attenuates 5-Flurouracil-Induced Intestinal Mucositis
AU - Lee, Jae Min
AU - Chun, Hoon-Jai
AU - Choi, Hyuk Soon
AU - Kim, Eun-Sun
AU - Seo, Yeon Seok
AU - Jeen, Yoon Tae
AU - Lee, Hong Sik
AU - Um, Soon-Ho
AU - Kim, Chul Hwan
AU - Sul, Dong Geun
PY - 2017/5/19
Y1 - 2017/5/19
N2 - Chemotherapy-induced mucositis is mediated by the release of proinflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including the protection of membrane lipids and macromolecules against oxidative damage. However, to date, there is little evidence on the effect of trace elements on intestinal mucositis after chemotherapy. This study investigated the protective effect of selenium against chemotherapy-induced mucositis in rats. Twenty-four 9-wk-old female Wistar rats were randomized to 4 groups: control, selenium, 5-fluorouracil (5-FU), and 5-FU plus selenium. Mucositis was induced by a single dose of 5-FU (400 mg/kg BW) via intraperitoneal injection, and selenium was administered by a single intraperitoneal dose of sodium selenite (0.2 mg/kg BW). Diarrhea and weight loss after 5-FU administration were attenuated by selenium treatment. The mean villus height in the 5-FU plus selenium group was significantly taller than rats administered with 5-FU alone, but not significantly different compared to the control group. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1β, P < 0.01; TNF-α, P < 0.05). These findings indicate that selenium protects the mucosa during chemotherapy via its anti-inflammatory effects and its suppression of cytotoxic cytokine production.
AB - Chemotherapy-induced mucositis is mediated by the release of proinflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including the protection of membrane lipids and macromolecules against oxidative damage. However, to date, there is little evidence on the effect of trace elements on intestinal mucositis after chemotherapy. This study investigated the protective effect of selenium against chemotherapy-induced mucositis in rats. Twenty-four 9-wk-old female Wistar rats were randomized to 4 groups: control, selenium, 5-fluorouracil (5-FU), and 5-FU plus selenium. Mucositis was induced by a single dose of 5-FU (400 mg/kg BW) via intraperitoneal injection, and selenium was administered by a single intraperitoneal dose of sodium selenite (0.2 mg/kg BW). Diarrhea and weight loss after 5-FU administration were attenuated by selenium treatment. The mean villus height in the 5-FU plus selenium group was significantly taller than rats administered with 5-FU alone, but not significantly different compared to the control group. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1β, P < 0.01; TNF-α, P < 0.05). These findings indicate that selenium protects the mucosa during chemotherapy via its anti-inflammatory effects and its suppression of cytotoxic cytokine production.
UR - http://www.scopus.com/inward/record.url?scp=85016233933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016233933&partnerID=8YFLogxK
U2 - 10.1080/01635581.2017.1300289
DO - 10.1080/01635581.2017.1300289
M3 - Article
C2 - 28353366
AN - SCOPUS:85016233933
VL - 69
SP - 616
EP - 622
JO - Nutrition and Cancer
JF - Nutrition and Cancer
SN - 0163-5581
IS - 4
ER -