Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

K. Y. Lee, J. H. Kim, Ick Chan Kwon, S. Y. Jeong

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

Original languageEnglish
Pages (from-to)1216-1219
Number of pages4
JournalColloid and Polymer Science
Volume278
Issue number12
DOIs
Publication statusPublished - 2000 Dec 28
Externally publishedYes

Fingerprint

Deoxycholic Acid
Chitosan
Doxorubicin
acids
Acids
Atomic force microscopy
atomic force microscopy
Fluorescence spectroscopy
Dynamic light scattering
delivery
light scattering
Nanoparticles
fluorescence
nanoparticles
spectroscopy

Keywords

  • Adriamycin
  • Chitosan
  • Deoxycholic acid
  • Nanoparticle
  • Self-aggregate

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Materials Chemistry
  • Colloid and Surface Chemistry

Cite this

Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin. / Lee, K. Y.; Kim, J. H.; Kwon, Ick Chan; Jeong, S. Y.

In: Colloid and Polymer Science, Vol. 278, No. 12, 28.12.2000, p. 1216-1219.

Research output: Contribution to journalArticle

Lee, K. Y. ; Kim, J. H. ; Kwon, Ick Chan ; Jeong, S. Y. / Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin. In: Colloid and Polymer Science. 2000 ; Vol. 278, No. 12. pp. 1216-1219.
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