Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin

K. Y. Lee, J. H. Kim, I. C. Kwon, S. Y. Jeong

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106 Citations (Scopus)

Abstract

A novel and simple method for delivery of adriamycin (ADR) was developed using self-aggregates of deoxycholic acid-modified chitosan. Deoxycholic acid was covalently conjugated to chitosan via EDC-mediated reaction to generate self-aggregated chitosan nanoparticles. ADR was physically entrapped inside the self-aggregates and the characteristics of ADR-loaded chitosan self-aggregates were analyzed by dynamic light scattering, fluorescence spectroscopy, and atomic force microscopy (AFM). The maximum amount of entrapped ADR reached 16.5 wt% of chitosan self-aggregates, suggesting a loading efficiency of 49.6 wt%. The size of ADR-loaded self-aggregates increased with increasing the loading content of ADR. AFM images showed spherical shape of ADR-loaded self-aggregates, and ADR was slowly released from chitosan self-aggregates in PBS solution (pH 7.2).

Original languageEnglish
Pages (from-to)1216-1219
Number of pages4
JournalColloid and Polymer Science
Volume278
Issue number12
DOIs
Publication statusPublished - 2000 Dec 28

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Keywords

  • Adriamycin
  • Chitosan
  • Deoxycholic acid
  • Nanoparticle
  • Self-aggregate

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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