Abstract
Hydrophobically modified glycol chitosan (hGC) conjugates spontaneously form self-assembled nanoparticles (NPs) in aqueous conditions, and glycol chitosan NPs (CNPs) have been extensively studied for the past few decades. For disease-specific theranostics, CNPs could be simply modified with imaging agents, and the hydrophobic domains of hGC are available for encapsulation of various drugs. Based on the excellent physiochemical and biological properties, CNPs have been investigated for multimodal imaging and target specific drug delivery. In particular, a recent application of CNPs has shown great potential as an efficient theranostic system because the CNPs could be utilized for a disease-specific theranostic delivery system of different imaging agents and therapeutics, simultaneously. Furthermore, various therapeutic agents including chemo-drugs, nucleotides, peptides, and photodynamic chemicals could be simply encapsulated into the CNPs through hydrophobic or charge-charge interactions. Under in vivo conditions, the encapsulated imaging agents and therapeutic drugs have been successfully delivered to targeted diseases. In this article, the overall research progress on CNPs is reviewed from early works. The current challenges of CNPs to overcome in theranostics are also discussed, and continuous studies would provide more opportunities for early diagnosis of diseases and personalized medicine.
| Original language | English |
|---|---|
| Pages (from-to) | 202-213 |
| Number of pages | 12 |
| Journal | Journal of Controlled Release |
| Volume | 193 |
| DOIs | |
| Publication status | Published - 2014 Nov 10 |
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ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Self-assembled glycol chitosan nanoparticles for disease-specific theranostics. / Yhee, Ji Young; Son, Sohee; Kim, Sun Hwa; Park, Kinam; Choi, Kuiwon; Kwon, Ick Chan.
In: Journal of Controlled Release, Vol. 193, 10.11.2014, p. 202-213.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Self-assembled glycol chitosan nanoparticles for disease-specific theranostics
AU - Yhee, Ji Young
AU - Son, Sohee
AU - Kim, Sun Hwa
AU - Park, Kinam
AU - Choi, Kuiwon
AU - Kwon, Ick Chan
PY - 2014/11/10
Y1 - 2014/11/10
N2 - Hydrophobically modified glycol chitosan (hGC) conjugates spontaneously form self-assembled nanoparticles (NPs) in aqueous conditions, and glycol chitosan NPs (CNPs) have been extensively studied for the past few decades. For disease-specific theranostics, CNPs could be simply modified with imaging agents, and the hydrophobic domains of hGC are available for encapsulation of various drugs. Based on the excellent physiochemical and biological properties, CNPs have been investigated for multimodal imaging and target specific drug delivery. In particular, a recent application of CNPs has shown great potential as an efficient theranostic system because the CNPs could be utilized for a disease-specific theranostic delivery system of different imaging agents and therapeutics, simultaneously. Furthermore, various therapeutic agents including chemo-drugs, nucleotides, peptides, and photodynamic chemicals could be simply encapsulated into the CNPs through hydrophobic or charge-charge interactions. Under in vivo conditions, the encapsulated imaging agents and therapeutic drugs have been successfully delivered to targeted diseases. In this article, the overall research progress on CNPs is reviewed from early works. The current challenges of CNPs to overcome in theranostics are also discussed, and continuous studies would provide more opportunities for early diagnosis of diseases and personalized medicine.
AB - Hydrophobically modified glycol chitosan (hGC) conjugates spontaneously form self-assembled nanoparticles (NPs) in aqueous conditions, and glycol chitosan NPs (CNPs) have been extensively studied for the past few decades. For disease-specific theranostics, CNPs could be simply modified with imaging agents, and the hydrophobic domains of hGC are available for encapsulation of various drugs. Based on the excellent physiochemical and biological properties, CNPs have been investigated for multimodal imaging and target specific drug delivery. In particular, a recent application of CNPs has shown great potential as an efficient theranostic system because the CNPs could be utilized for a disease-specific theranostic delivery system of different imaging agents and therapeutics, simultaneously. Furthermore, various therapeutic agents including chemo-drugs, nucleotides, peptides, and photodynamic chemicals could be simply encapsulated into the CNPs through hydrophobic or charge-charge interactions. Under in vivo conditions, the encapsulated imaging agents and therapeutic drugs have been successfully delivered to targeted diseases. In this article, the overall research progress on CNPs is reviewed from early works. The current challenges of CNPs to overcome in theranostics are also discussed, and continuous studies would provide more opportunities for early diagnosis of diseases and personalized medicine.
KW - Glycol chitosan
KW - Nanoparticles
KW - Targeted delivery
KW - Theranostics
UR - http://www.scopus.com/inward/record.url?scp=84908277949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908277949&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2014.05.009
DO - 10.1016/j.jconrel.2014.05.009
M3 - Article
C2 - 24845129
AN - SCOPUS:84908277949
VL - 193
SP - 202
EP - 213
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -