Self-assembled nanoparticles based on linoleic-acid modified carboxymethyl-chitosan as carrier of adriamycin (ADR)

Chenguang Liu, Wenwen Fan, Xiguang Chen, Chengsheng Liu, Xianghong Meng, Hyun Jin Park

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8 nm, with a size range from 222.8 nm to 1028 nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading experiments indicate that the loading capacity and efficiency increase with increasing concentration of ADR. ADR is slowly released from chitosan self-aggregates for about 3 days. Furthermore, the effects of drug controlled release become more obvious on increasing the pH value.

Original languageEnglish
Pages (from-to)e125-e129
JournalCurrent Applied Physics
Volume7
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2007 Apr

Keywords

  • Adriamycin
  • Carboxymethyl-chitosan
  • Linoleic-acid
  • Nanoparticles

ASJC Scopus subject areas

  • Materials Science(all)
  • Physics and Astronomy(all)

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