Self-assembled nanoparticles of bile acid-modified glycol chitosans and their applications for cancer therapy

Kwangmeyung Kim, Jong Ho Kim, Sungwon Kim, Hesson Chung, Kuiwon Choi, Chan Kwon Ick, Hyung Park Jae, Yoo Shin Kim, Rang Won Park, In San Kim, Young Jeong Seo

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of 1-ethyl-3-(3- dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The BGC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.

Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalMacromolecular Research
Volume13
Issue number3
DOIs
Publication statusPublished - 2005 Jun

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Keywords

  • Cancer therapy
  • EPR effect
  • Glycol chitosan
  • Nanoparticle

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Kim, K., Kim, J. H., Kim, S., Chung, H., Choi, K., Ick, C. K., Jae, H. P., Kim, Y. S., Park, R. W., Kim, I. S., & Seo, Y. J. (2005). Self-assembled nanoparticles of bile acid-modified glycol chitosans and their applications for cancer therapy. Macromolecular Research, 13(3), 167-175. https://doi.org/10.1007/BF03219048