Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media: A facile route to a minimal polymethine dye for NIR fluorescence imaging

Jeongyun Heo; Chang Keun Lim; Dong Ryeol Whang; Jiyoung Shin; Seo Young Jeong; Soo Young Park; Ick Chan Kwon; Sehoon Kim

doi:10.1002/chem.201103042

Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media: A facile route to a minimal polymethine dye for NIR fluorescence imaging

Jeongyun Heo, Chang Keun Lim, Dong Ryeol Whang, Jiyoung Shin, Seo Young Jeong, Soo Young Park, Ick Chan Kwon, Sehoon Kim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Colorless 1,3-bis(dicyanomethylidene)indan is an organic acid (pK _a≈3.0) that turns blue in polar media owing to self-deprotonation. Moreover, its colored conjugate base shows potential as a minimal anionic polymethine dye for probing biomolecules in cells and in vivo through noncovalent complexation and near-infrared fluorescence signaling.

Original language	English
Pages (from-to)	8699-8704
Number of pages	6
Journal	Chemistry - A European Journal
Volume	18
Issue number	28
DOIs	https://doi.org/10.1002/chem.201103042
Publication status	Published - 2012 Jul 9
Externally published	Yes

Keywords

fluorescence
fluorescent probes
imaging agents
near-infrared spectroscopy
polymethines

ASJC Scopus subject areas

Chemistry(all)

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10.1002/chem.201103042

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title = "Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media: A facile route to a minimal polymethine dye for NIR fluorescence imaging",

abstract = "Colorless 1,3-bis(dicyanomethylidene)indan is an organic acid (pK a≈3.0) that turns blue in polar media owing to self-deprotonation. Moreover, its colored conjugate base shows potential as a minimal anionic polymethine dye for probing biomolecules in cells and in vivo through noncovalent complexation and near-infrared fluorescence signaling.",

keywords = "fluorescence, fluorescent probes, imaging agents, near-infrared spectroscopy, polymethines",

author = "Jeongyun Heo and Lim, {Chang Keun} and Whang, {Dong Ryeol} and Jiyoung Shin and Jeong, {Seo Young} and Park, {Soo Young} and Kwon, {Ick Chan} and Sehoon Kim",

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T1 - Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media

T2 - A facile route to a minimal polymethine dye for NIR fluorescence imaging

AU - Heo, Jeongyun

AU - Lim, Chang Keun

AU - Whang, Dong Ryeol

AU - Shin, Jiyoung

AU - Jeong, Seo Young

AU - Park, Soo Young

AU - Kwon, Ick Chan

AU - Kim, Sehoon

PY - 2012/7/9

Y1 - 2012/7/9

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AB - Colorless 1,3-bis(dicyanomethylidene)indan is an organic acid (pK a≈3.0) that turns blue in polar media owing to self-deprotonation. Moreover, its colored conjugate base shows potential as a minimal anionic polymethine dye for probing biomolecules in cells and in vivo through noncovalent complexation and near-infrared fluorescence signaling.

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KW - fluorescent probes

KW - imaging agents

KW - near-infrared spectroscopy

KW - polymethines

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Self-deprotonation and colorization of 1,3-bis(dicyanomethylidene)indan in polar media: A facile route to a minimal polymethine dye for NIR fluorescence imaging

Abstract

Keywords

ASJC Scopus subject areas

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