Self-vasculaizing three dimensional collagen by recombinant bacteriophages

Junghyo Yoon, Nuriye Korkmaz, Sewoon Han, Chang Hoon Nam, Seok Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Developing tissue inducing vascularization is of great important to the functional tissue design. We have genetically engineered recombinant bacteriophage displayed vascular endothelial cell growth factor (VEGF) on their coat proteins and combined it on the type I collagen scaffold, natural extracellular matrix. This functionalized tissue can lead angiogenesis and capillary morphogenesis itself without any VEGF supply. We showed that the functionalized collagen scaffold with VEGF conjugated recombinant bacteriophage was able to induce angiogenesis as well as capillary morphogenesis in three dimensions. There functionalized scaffold offers promising solution for therapies for graft surgery, such as acceleration of recovery after skin graft, or as intentional leading of vascularizing for preventing parenchyma necrosis.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1147-1149
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 2012 Oct 282012 Nov 1

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period12/10/2812/11/1

Keywords

  • Angiogenesis
  • Bacteriophage
  • Collagen
  • Vascular endothelial cell growth factor

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Yoon, J., Korkmaz, N., Han, S., Nam, C. H., & Chung, S. (2012). Self-vasculaizing three dimensional collagen by recombinant bacteriophages. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1147-1149). (Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012). Chemical and Biological Microsystems Society.