Senescent tumor cells building three-dimensional tumor clusters

Hyun Gyu Lee, June Hoan Kim, Woong Sun, Sung-Gil Chi, Wonshik Choi, Kyoung Jin Lee

Research output: Contribution to journalArticle

Abstract

Cellular senescence, a permanent cell-cycle arrest, is a common yet intriguing phenomenon, in which its beneficial significance for biological organisms has only begun to be explored. Among others, senescent cells are able to transform tissue structures around them. Tumor cells, whose hallmark is their ability to proliferate indefinitely, are not free from the phenomenon. Here, we report a remarkable observation where senescent cells in a dense mono-layer of breast cancer colony act as aggregating centers for non-senescent cells in their vicinity. Consequently, the senescent cells actively form localized 3D cell-clusters in a confluent 2D tumor layer. The biophysical mechanism underpinning the surprising phenomenon primarily involves mitotic cell-rounding, dynamic and differential cell attachments, and cellular chemotaxis. By incorporating these few biophysical factors, we were able to recapitulate the experimental observation via a cellular Potts Model.

Original languageEnglish
Article number10503
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Neoplasms
Observation
Aptitude
Cell Aging
Chemotaxis
Cell Cycle Checkpoints
Breast Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Senescent tumor cells building three-dimensional tumor clusters. / Lee, Hyun Gyu; Kim, June Hoan; Sun, Woong; Chi, Sung-Gil; Choi, Wonshik; Lee, Kyoung Jin.

In: Scientific Reports, Vol. 8, No. 1, 10503, 01.12.2018.

Research output: Contribution to journalArticle

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