Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang; Kwang No Park; Jun P. Kim; Sang Jun Sim; Oh J. Kwon; Young Geun Han; Kyung Shik Lee

doi:10.1364/OE.17.003855

Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang, Kwang No Park, Jun P. Kim, Sang Jun Sim, Oh J. Kwon, Young Geun Han, Kyung Shik Lee

Research output: Contribution to journal › Article

78 Citations (Scopus)

Abstract

We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

Original language	English
Pages (from-to)	3855-3860
Number of pages	6
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003855
Publication status	Published - 2009 Mar 2
Externally published	Yes

Fingerprint

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

Cite this

Jang, H. S., Park, K. N., Kim, J. P., Sim, S. J., Kwon, O. J., Han, Y. G., & Lee, K. S. (2009). Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface. Optics Express, 17(5), 3855-3860. https://doi.org/10.1364/OE.17.003855

@article{1eedbe39851247fabd79ecc99cc46ccc,

title = "Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface",

abstract = "We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.",

author = "Jang, {Hyun Soo} and Park, {Kwang No} and Kim, {Jun P.} and Sim, {Sang Jun} and Kwon, {Oh J.} and Han, {Young Geun} and Lee, {Kyung Shik}",

year = "2009",

month = "3",

day = "2",

doi = "10.1364/OE.17.003855",

language = "English",

volume = "17",

pages = "3855--3860",

journal = "Optics Express",

issn = "1094-4087",

publisher = "The Optical Society",

number = "5",

}

TY - JOUR

T1 - Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

AU - Jang, Hyun Soo

AU - Park, Kwang No

AU - Kim, Jun P.

AU - Sim, Sang Jun

AU - Kwon, Oh J.

AU - Han, Young Geun

AU - Lee, Kyung Shik

PY - 2009/3/2

Y1 - 2009/3/2

N2 - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

AB - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

UR - http://www.scopus.com/inward/record.url?scp=61549136731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61549136731&partnerID=8YFLogxK

U2 - 10.1364/OE.17.003855

DO - 10.1364/OE.17.003855

M3 - Article

C2 - 19259227

AN - SCOPUS:61549136731

VL - 17

SP - 3855

EP - 3860

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 5

ER -

Access to Document

10.1364/OE.17.003855