Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang; Kwang No Park; Jun P. Kim; Sang Jun Sim; Oh J. Kwon; Young Geun Han; Kyung Shik Lee

doi:10.1364/OE.17.003855

Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang, Kwang No Park, Jun P. Kim, Sang Jun Sim, Oh J. Kwon, Young Geun Han, Kyung Shik Lee

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

Original language	English
Pages (from-to)	3855-3860
Number of pages	6
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003855
Publication status	Published - 2009 Mar 2
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

Access to Document

10.1364/OE.17.003855

Cite this

@article{1eedbe39851247fabd79ecc99cc46ccc,

title = "Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface",

abstract = "We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.",

author = "Jang, {Hyun Soo} and Park, {Kwang No} and Kim, {Jun P.} and Sim, {Sang Jun} and Kwon, {Oh J.} and Han, {Young Geun} and Lee, {Kyung Shik}",

year = "2009",

month = mar,

day = "2",

doi = "10.1364/OE.17.003855",

language = "English",

volume = "17",

pages = "3855--3860",

journal = "Optics Express",

issn = "1094-4087",

publisher = "The Optical Society",

number = "5",

}

TY - JOUR

T1 - Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

AU - Jang, Hyun Soo

AU - Park, Kwang No

AU - Kim, Jun P.

AU - Sim, Sang Jun

AU - Kwon, Oh J.

AU - Han, Young Geun

AU - Lee, Kyung Shik

PY - 2009/3/2

Y1 - 2009/3/2

N2 - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

AB - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

UR - http://www.scopus.com/inward/record.url?scp=61549136731&partnerID=8YFLogxK

U2 - 10.1364/OE.17.003855

DO - 10.1364/OE.17.003855

M3 - Article

C2 - 19259227

AN - SCOPUS:61549136731

VL - 17

SP - 3855

EP - 3860

JO - Optics Express

JF - Optics Express

SN - 1094-4087

IS - 5

ER -

Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this