Abstract
We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.
| Original language | English |
|---|---|
| Pages (from-to) | 3855-3860 |
| Number of pages | 6 |
| Journal | Optics Express |
| Volume | 17 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2009 Mar 2 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface. / Jang, Hyun Soo; Park, Kwang No; Kim, Jun P.; Sim, Sang Jun; Kwon, Oh J.; Han, Young Geun; Lee, Kyung Shik.
In: Optics Express, Vol. 17, No. 5, 02.03.2009, p. 3855-3860.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface
AU - Jang, Hyun Soo
AU - Park, Kwang No
AU - Kim, Jun P.
AU - Sim, Sang Jun
AU - Kwon, Oh J.
AU - Han, Young Geun
AU - Lee, Kyung Shik
PY - 2009/3/2
Y1 - 2009/3/2
N2 - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.
AB - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.
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UR - http://www.scopus.com/inward/citedby.url?scp=61549136731&partnerID=8YFLogxK
U2 - 10.1364/OE.17.003855
DO - 10.1364/OE.17.003855
M3 - Article
VL - 17
SP - 3855
EP - 3860
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 5
ER -