Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang; Kwang No Park; Jun P. Kim; Sang Jun Sim; Oh J. Kwon; Young Geun Han; Kyung Shik Lee

doi:10.1364/OE.17.003855

Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang, Kwang No Park, Jun P. Kim, Sang Jun Sim, Oh J. Kwon, Young Geun Han, Kyung Shik Lee

Research output: Contribution to journal › Article › peer-review

95 Citations (Scopus)

Abstract

We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

Original language	English
Pages (from-to)	3855-3860
Number of pages	6
Journal	Optics Express
Volume	17
Issue number	5
DOIs	https://doi.org/10.1364/OE.17.003855
Publication status	Published - 2009 Mar 2
Externally published	Yes

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface",

abstract = "We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.",

author = "Jang, {Hyun Soo} and Park, {Kwang No} and Kim, {Jun P.} and Sim, {Sang Jun} and Kwon, {Oh J.} and Han, {Young Geun} and Lee, {Kyung Shik}",

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AU - Jang, Hyun Soo

AU - Park, Kwang No

AU - Kim, Jun P.

AU - Sim, Sang Jun

AU - Kwon, Oh J.

AU - Han, Young Geun

AU - Lee, Kyung Shik

PY - 2009/3/2

Y1 - 2009/3/2

N2 - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

AB - We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

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JF - Optics Express

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Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Abstract

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