Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface

Hyun Soo Jang, Kwang No Park, Jun P. Kim, Sang Jun Sim, Oh J. Kwon, Young Geun Han, Kyung Shik Lee

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Abstract

We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.

Original languageEnglish
Pages (from-to)3855-3860
Number of pages6
JournalOptics Express
Volume17
Issue number5
DOIs
Publication statusPublished - 2009 Mar 2
Externally publishedYes

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Jang, H. S., Park, K. N., Kim, J. P., Sim, S. J., Kwon, O. J., Han, Y. G., & Lee, K. S. (2009). Sensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface. Optics Express, 17(5), 3855-3860. https://doi.org/10.1364/OE.17.003855