Abstract
We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is ∼2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.
Original language | English |
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Pages (from-to) | 3855-3860 |
Number of pages | 6 |
Journal | Optics Express |
Volume | 17 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2009 Mar 2 |
Externally published | Yes |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics