Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach

Donghoon Han, Yang Rae Kim, Jeong Wook Oh, Jong Seung Kim, Hasuck Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a sensitive and selective electrochemical sensor for the detection of mercury(II) ions in aqueous media. This electrochemical sensor is based on the molecular beacon which involves an electroactive, ferrocene-labeled DNA hairpin structure and provides strategically selective binding of thyminethymine mismatch for Hg2+ ions. The modified electrode showed a voltammetric signal due to an one-step redox reaction of the surface-confined ferrocenyl moiety. The "signal-on" upon mercury binding could be attributed to a change in conformation from open structure to restricted hairpin structure. The molecular beacon mercury(II) ion sensor was amenable to regeneration by unfolding the ferrocene-labeled DNA in 10 μM cysteine.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages964-966
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Electrochemical detection

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Han, D., Kim, Y. R., Oh, J. W., Kim, J. S., & Kim, H. (2009). Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 964-966). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.