Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach

Donghoon Han, Yang Rae Kim, Jeong Wook Oh, Jong Seung Kim, Hasuck Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a sensitive and selective electrochemical sensor for the detection of mercury(II) ions in aqueous media. This electrochemical sensor is based on the molecular beacon which involves an electroactive, ferrocene-labeled DNA hairpin structure and provides strategically selective binding of thyminethymine mismatch for Hg2+ ions. The modified electrode showed a voltammetric signal due to an one-step redox reaction of the surface-confined ferrocenyl moiety. The "signal-on" upon mercury binding could be attributed to a change in conformation from open structure to restricted hairpin structure. The molecular beacon mercury(II) ion sensor was amenable to regeneration by unfolding the ferrocene-labeled DNA in 10 μM cysteine.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages964-966
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Fingerprint

Electrochemical sensors
Mercury
Ions
DNA
Redox reactions
Cysteine
Conformations
Electrodes
Sensors
ferrocene

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Han, D., Kim, Y. R., Oh, J. W., Kim, J. S., & Kim, H. (2009). Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 964-966). Chemical and Biological Microsystems Society.

Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. / Han, Donghoon; Kim, Yang Rae; Oh, Jeong Wook; Kim, Jong Seung; Kim, Hasuck.

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 964-966.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Han, D, Kim, YR, Oh, JW, Kim, JS & Kim, H 2009, Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 964-966, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of, 09/11/1.
Han D, Kim YR, Oh JW, Kim JS, Kim H. Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 964-966
Han, Donghoon ; Kim, Yang Rae ; Oh, Jeong Wook ; Kim, Jong Seung ; Kim, Hasuck. / Sensitive, selective and resuable electrochemical sensor for mercury(II) based on molecular beacon approach. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 964-966
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