Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Kyoung Ran Kim, Yong Deok Lee, Taemin Lee, Byeong Su Kim, Sehoon Kim, Dae Ro Ahn

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Sentinel lymph nodes (SLNs) are the first lymph nodes which cancer cells reach after traveling through lymphatic vessels from the primary tumor. Evaluating the nodal status is crucial in accurate staging of human cancers and accordingly determines prognosis and the most appropriate treatment. The commonly used methods for SLN identification in clinics are based on employment of a colloid of radionuclide or injection of a small dye. Although these methods have certainly contributed to improve surgical practice, new imaging materials are still required to overcome drawbacks of the techniques such as inconvenience of handling radioactive materials and short retention time of small dyes in SLNs. Here, we prepare a fluorescence-labeled DNA tetrahedron and perform SLN imaging by using the DNA nanoconstruct. With a successful identification of SLNs by the DNA nanoconstruct, we suggest that DNA tetrahedron hold great promises for clinical applications.

Original languageEnglish
Pages (from-to)5226-5235
Number of pages10
JournalBiomaterials
Volume34
Issue number21
DOIs
Publication statusPublished - 2013 Jul 1
Externally publishedYes

Keywords

  • Biocompatibility
  • Cancer
  • DNA tetrahedron
  • Invivo imaging
  • Sentinel lymph node

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint Dive into the research topics of 'Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron'. Together they form a unique fingerprint.

  • Cite this