Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic

Byoung Kuk Na, Jin Soo Lee, Gu Choul Shin, Ju Mi Shin, Joo Yeon Lee, Jae Keun Chung, Dong Ryong Ha, Jong Koo Lee, Sang Hyuk Ma, Hae Wol Cho, Chun Kang, Woo Joo Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To characterize the genetic properties of currently circulating measles viruses in Korea, the complete nucleotide sequences of hemagglutinin (H) protein and nucleoprotein (N) genes of Korean viruses were analyzed. The entire genes of H and N were directly amplified by RT-PCR from each clinical specimen and sequenced. Sequence analyses of H and N genes indicated that all Korean viruses had a high degree of homology (> 99.8%) when compared with each other. The Korean viruses differed from other wild-type viruses by as much as 6.8% in the H gene and 6.5% in the N gene at the nucleotide level. The deduced amino acid variability was up to 6.4% for the H protein and up to 6.5% for the N protein. Phylogenetic analyses of nucleotide sequences and deduced amino acid sequences of the H and N genes revealed that all Korean viruses were grouped into the clade H1.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalVirus Research
Volume81
Issue number1-2
DOIs
Publication statusPublished - 2001 Dec 4

Keywords

  • Hemagglutinin
  • Measles virus
  • Nucleoprotein
  • Sequence

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic'. Together they form a unique fingerprint.

  • Cite this

    Na, B. K., Lee, J. S., Shin, G. C., Mi Shin, J., Lee, J. Y., Chung, J. K., Ha, D. R., Lee, J. K., Ma, S. H., Cho, H. W., Kang, C., & Kim, W. J. (2001). Sequence analysis of hemagglutinin and nucleoprotein genes of measles viruses isolated in Korea during the 2000 epidemic. Virus Research, 81(1-2), 143-149. https://doi.org/10.1016/S0168-1702(01)00346-X