Sequence and phylogenetic analyses of human T cell lymphotropic virus type 1 from a Brazilian woman with adult T cell leukemia

Comparison with virus strains from South America and the Caribbean basin

Ki-Joon Song, V. R. Nerurkar, A. J. Pereira-Cortez, M. Yamamoto, H. Taguchi, I. Miyoshi, R. Yanagihara

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in South America and the Caribbean basin. To clarify the genetic and phylogenetic relationship between an HTLV-1 strain isolated from a Brazilian woman with adult T cell leukemia and vital isolates from elsewhere in South America and from other geographic regions, selected regions of the gag, pol, env, and pX genes were amplified and directly sequenced. The overall sequence similarities between the Brazil-R-1 strain and the Japanese prototype ATK strain were 98.7% based on 1,295 nucleotides and 99.1% based on 429 amino acids. Phylogenetic analysis indicated that strain Brazil-R-1 clustered with other Brazilian and South American HTLV-1 isolates and was more closely related to Caribbean isolates from Martinique and Guadeloupe than to virus strains from other geographic regions. These data suggest a common source of HTLV-1 infection in the Caribbean basin and South America.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume52
Issue number1
Publication statusPublished - 1995 Jan 1
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
South America
Sequence Analysis
Viruses
T-Lymphocytes
Brazil
pX Genes
Martinique
Guadeloupe
pol Genes
gag Genes
env Genes
Virus Diseases
Nucleotides
Amino Acids

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Sequence and phylogenetic analyses of human T cell lymphotropic virus type 1 from a Brazilian woman with adult T cell leukemia : Comparison with virus strains from South America and the Caribbean basin. / Song, Ki-Joon; Nerurkar, V. R.; Pereira-Cortez, A. J.; Yamamoto, M.; Taguchi, H.; Miyoshi, I.; Yanagihara, R.

In: American Journal of Tropical Medicine and Hygiene, Vol. 52, No. 1, 01.01.1995, p. 101-108.

Research output: Contribution to journalArticle

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