Sequential simulation computed tomography allows assessment of internal rectal movements during preoperative chemoradiotherapy in rectal cancer

Dae-Sik Yang, Jung Lee, Won Sup Yoon, Nam Lee, Young Park, Suk Lee, Chul Yong Kim

Research output: Contribution to journalArticle

Abstract

Purposes: The purpose of this study was to assess the internal rectal movement and to determine the factors related to extensive internal rectal movement using sequential simulation computed tomography (CT) images. Materials and Methods: From 2010 to 2015, 96 patients receiving long-course preoperative chemoradiotherapy were included in our retrospective study. The initial simulation CT (Isim-CT) and follow-up simulation CT (Fsim-CT) for a boost were registered according to the isocenters and bony structure. The rectums on Isim-CT and Fsim-CT were compared on four different axial planes as follows: (1) lower pubis symphysis (AX VERYLOW ), (2) upper pubis symphysis (AX LOW ), (3) superior rectum (AX HIGH ), and (4) middle of AX LOW and AX HIGH (AX MID ). The involved rectum in the planning target volume was evaluated. The maximal radial distances (MRD), the necessary radius from the end of Isim-CT rectum to cover entire Fsim-CT rectum, and the common area rate (CAR) of the rectum (CAR, (Isim-CT∩Fsim-CT)/(Isim-CT)) were measured. Linear regression tests for the MRDs and logistic regression tests for the CARs were conducted. Results: The mean ± standard deviation (mm) of MRDs and CAR <80% for AX VERYLOW , AX LOW , AX MID , and AX HIGH were 2.3 ± 2.5 and 8.9%, 3.0 ± 3.7 and 17.4%, 4.0 ± 5.2 and 27.1%, and 4.1 ± 5.2 and 25%, respectively. For MRDs and CARs, a higher axial level (AX VERYLOW /AX MID-HIGH , P = 0.018 and P = 0.034, respectively), larger bladder volume (P = 0.054 and P = 0.017, respectively), smaller bowel gas extent (small/marked, P = 0.014 and P = 0.001, respectively), and increased bowel gas change (decrease/increase, both P < 0.001) in rectum were associated with extensive internal rectal movement in multivariate analyses. Conclusions: As a result of following internal rectal movement through sequential simulation CT, the rectum above the pubis symphysis needs a larger margin, and bladder volume and bowel gas should be closely observed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Cancer Research and Therapeutics
Volume15
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Chemoradiotherapy
Rectal Neoplasms
Rectum
Tomography
Pubic Bone
Gases
Urinary Bladder
Linear Models
Multivariate Analysis
Retrospective Studies
Logistic Models

Keywords

  • Organ movement
  • preoperative radiotherapy
  • rectal cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{1315d17447674e14b7af9ab17ec03a2b,
title = "Sequential simulation computed tomography allows assessment of internal rectal movements during preoperative chemoradiotherapy in rectal cancer",
abstract = "Purposes: The purpose of this study was to assess the internal rectal movement and to determine the factors related to extensive internal rectal movement using sequential simulation computed tomography (CT) images. Materials and Methods: From 2010 to 2015, 96 patients receiving long-course preoperative chemoradiotherapy were included in our retrospective study. The initial simulation CT (Isim-CT) and follow-up simulation CT (Fsim-CT) for a boost were registered according to the isocenters and bony structure. The rectums on Isim-CT and Fsim-CT were compared on four different axial planes as follows: (1) lower pubis symphysis (AX VERYLOW ), (2) upper pubis symphysis (AX LOW ), (3) superior rectum (AX HIGH ), and (4) middle of AX LOW and AX HIGH (AX MID ). The involved rectum in the planning target volume was evaluated. The maximal radial distances (MRD), the necessary radius from the end of Isim-CT rectum to cover entire Fsim-CT rectum, and the common area rate (CAR) of the rectum (CAR, (Isim-CT∩Fsim-CT)/(Isim-CT)) were measured. Linear regression tests for the MRDs and logistic regression tests for the CARs were conducted. Results: The mean ± standard deviation (mm) of MRDs and CAR <80{\%} for AX VERYLOW , AX LOW , AX MID , and AX HIGH were 2.3 ± 2.5 and 8.9{\%}, 3.0 ± 3.7 and 17.4{\%}, 4.0 ± 5.2 and 27.1{\%}, and 4.1 ± 5.2 and 25{\%}, respectively. For MRDs and CARs, a higher axial level (AX VERYLOW /AX MID-HIGH , P = 0.018 and P = 0.034, respectively), larger bladder volume (P = 0.054 and P = 0.017, respectively), smaller bowel gas extent (small/marked, P = 0.014 and P = 0.001, respectively), and increased bowel gas change (decrease/increase, both P < 0.001) in rectum were associated with extensive internal rectal movement in multivariate analyses. Conclusions: As a result of following internal rectal movement through sequential simulation CT, the rectum above the pubis symphysis needs a larger margin, and bladder volume and bowel gas should be closely observed.",
keywords = "Organ movement, preoperative radiotherapy, rectal cancer",
author = "Dae-Sik Yang and Jung Lee and Yoon, {Won Sup} and Nam Lee and Young Park and Suk Lee and Kim, {Chul Yong}",
year = "2019",
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doi = "10.4103/jcrt.JCRT_227_17",
language = "English",
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T1 - Sequential simulation computed tomography allows assessment of internal rectal movements during preoperative chemoradiotherapy in rectal cancer

AU - Yang, Dae-Sik

AU - Lee, Jung

AU - Yoon, Won Sup

AU - Lee, Nam

AU - Park, Young

AU - Lee, Suk

AU - Kim, Chul Yong

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purposes: The purpose of this study was to assess the internal rectal movement and to determine the factors related to extensive internal rectal movement using sequential simulation computed tomography (CT) images. Materials and Methods: From 2010 to 2015, 96 patients receiving long-course preoperative chemoradiotherapy were included in our retrospective study. The initial simulation CT (Isim-CT) and follow-up simulation CT (Fsim-CT) for a boost were registered according to the isocenters and bony structure. The rectums on Isim-CT and Fsim-CT were compared on four different axial planes as follows: (1) lower pubis symphysis (AX VERYLOW ), (2) upper pubis symphysis (AX LOW ), (3) superior rectum (AX HIGH ), and (4) middle of AX LOW and AX HIGH (AX MID ). The involved rectum in the planning target volume was evaluated. The maximal radial distances (MRD), the necessary radius from the end of Isim-CT rectum to cover entire Fsim-CT rectum, and the common area rate (CAR) of the rectum (CAR, (Isim-CT∩Fsim-CT)/(Isim-CT)) were measured. Linear regression tests for the MRDs and logistic regression tests for the CARs were conducted. Results: The mean ± standard deviation (mm) of MRDs and CAR <80% for AX VERYLOW , AX LOW , AX MID , and AX HIGH were 2.3 ± 2.5 and 8.9%, 3.0 ± 3.7 and 17.4%, 4.0 ± 5.2 and 27.1%, and 4.1 ± 5.2 and 25%, respectively. For MRDs and CARs, a higher axial level (AX VERYLOW /AX MID-HIGH , P = 0.018 and P = 0.034, respectively), larger bladder volume (P = 0.054 and P = 0.017, respectively), smaller bowel gas extent (small/marked, P = 0.014 and P = 0.001, respectively), and increased bowel gas change (decrease/increase, both P < 0.001) in rectum were associated with extensive internal rectal movement in multivariate analyses. Conclusions: As a result of following internal rectal movement through sequential simulation CT, the rectum above the pubis symphysis needs a larger margin, and bladder volume and bowel gas should be closely observed.

AB - Purposes: The purpose of this study was to assess the internal rectal movement and to determine the factors related to extensive internal rectal movement using sequential simulation computed tomography (CT) images. Materials and Methods: From 2010 to 2015, 96 patients receiving long-course preoperative chemoradiotherapy were included in our retrospective study. The initial simulation CT (Isim-CT) and follow-up simulation CT (Fsim-CT) for a boost were registered according to the isocenters and bony structure. The rectums on Isim-CT and Fsim-CT were compared on four different axial planes as follows: (1) lower pubis symphysis (AX VERYLOW ), (2) upper pubis symphysis (AX LOW ), (3) superior rectum (AX HIGH ), and (4) middle of AX LOW and AX HIGH (AX MID ). The involved rectum in the planning target volume was evaluated. The maximal radial distances (MRD), the necessary radius from the end of Isim-CT rectum to cover entire Fsim-CT rectum, and the common area rate (CAR) of the rectum (CAR, (Isim-CT∩Fsim-CT)/(Isim-CT)) were measured. Linear regression tests for the MRDs and logistic regression tests for the CARs were conducted. Results: The mean ± standard deviation (mm) of MRDs and CAR <80% for AX VERYLOW , AX LOW , AX MID , and AX HIGH were 2.3 ± 2.5 and 8.9%, 3.0 ± 3.7 and 17.4%, 4.0 ± 5.2 and 27.1%, and 4.1 ± 5.2 and 25%, respectively. For MRDs and CARs, a higher axial level (AX VERYLOW /AX MID-HIGH , P = 0.018 and P = 0.034, respectively), larger bladder volume (P = 0.054 and P = 0.017, respectively), smaller bowel gas extent (small/marked, P = 0.014 and P = 0.001, respectively), and increased bowel gas change (decrease/increase, both P < 0.001) in rectum were associated with extensive internal rectal movement in multivariate analyses. Conclusions: As a result of following internal rectal movement through sequential simulation CT, the rectum above the pubis symphysis needs a larger margin, and bladder volume and bowel gas should be closely observed.

KW - Organ movement

KW - preoperative radiotherapy

KW - rectal cancer

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