TY - JOUR
T1 - Serially increasing change in lipoprotein(a) concentration has predictive value in acute vascular events
AU - Hong, Soon Jun
AU - Seo, Hong Seog
AU - Park, Chang Gyu
AU - Rha, Seung Woon
AU - Oh, Dong Joo
AU - Ro, Young Moo
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/7
Y1 - 2005/7
N2 - Background: Lipoprotein(a) (Lp(a)) has been regarded in some studies as an independent risk factor of atherosclerotic vascular disease. However, the use of a baseline plasma Lp(a) concentration as a screening tool for future acute vascular events (AVE) is controversial. We therefore investigated whether progressively increasing change in plasma Lp(a) concentration is associated with the development of AVE. Methods: We investigated prospective analyses of 985 participants (464 women and 521 men) who had either clinically evident vascular disease (VD group, n = 443) or its risk factor(s) (RF group, n = 542). Blood samples were taken from all participants every six months to measure inflammatory markers such as Lp(a) and C-reactive protein during a 10-year follow-up period. Results: During the follow-up, 223 new cases of myocardial infarction, stroke, and peripheral arterial disease were identified. In the RF group, the relative risk of positive Δ Lp(a) for predicting AVE was 4.36 (95% confidence interval [CI] 1.76-10.85; P = 0.002). In the VD group, the relative risk of positive Δ Lp(a) for predicting AVE was 6.35 (95% CI 3.68-10.97; P < 0.001). Conclusions: These results suggest that a progressively increasing change in Lp(a) concentration has a highly significant predictive value in AVE in both the VD and the RF groups.
AB - Background: Lipoprotein(a) (Lp(a)) has been regarded in some studies as an independent risk factor of atherosclerotic vascular disease. However, the use of a baseline plasma Lp(a) concentration as a screening tool for future acute vascular events (AVE) is controversial. We therefore investigated whether progressively increasing change in plasma Lp(a) concentration is associated with the development of AVE. Methods: We investigated prospective analyses of 985 participants (464 women and 521 men) who had either clinically evident vascular disease (VD group, n = 443) or its risk factor(s) (RF group, n = 542). Blood samples were taken from all participants every six months to measure inflammatory markers such as Lp(a) and C-reactive protein during a 10-year follow-up period. Results: During the follow-up, 223 new cases of myocardial infarction, stroke, and peripheral arterial disease were identified. In the RF group, the relative risk of positive Δ Lp(a) for predicting AVE was 4.36 (95% confidence interval [CI] 1.76-10.85; P = 0.002). In the VD group, the relative risk of positive Δ Lp(a) for predicting AVE was 6.35 (95% CI 3.68-10.97; P < 0.001). Conclusions: These results suggest that a progressively increasing change in Lp(a) concentration has a highly significant predictive value in AVE in both the VD and the RF groups.
UR - http://www.scopus.com/inward/record.url?scp=21844470990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21844470990&partnerID=8YFLogxK
U2 - 10.1258/0004563054255560
DO - 10.1258/0004563054255560
M3 - Article
C2 - 16025613
AN - SCOPUS:21844470990
VL - 42
SP - 285
EP - 291
JO - Annals of Clinical Biochemistry
JF - Annals of Clinical Biochemistry
SN - 0004-5632
IS - 4
ER -