Abstract
Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
| Original language | English |
|---|---|
| Pages (from-to) | 335-341 |
| Number of pages | 7 |
| Journal | Annals of Laboratory Medicine |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Jul 1 |
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Keywords
- Adverse transfusion reactions
- Hemovigilance system
- Korea
- Trace back system
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014). / Kwon, Jeong Ran; Won, Eun Jeong; Jo, Hyun Jung; Choi, Sae Rom; Lee, Kyoungyul; Kim, Sinyoung; Ahn, Hyeong Sik; Choi, Young Sill; Cho, Duck; Lee, Dong Han.
In: Annals of Laboratory Medicine, Vol. 36, No. 4, 01.07.2016, p. 335-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014)
AU - Kwon, Jeong Ran
AU - Won, Eun Jeong
AU - Jo, Hyun Jung
AU - Choi, Sae Rom
AU - Lee, Kyoungyul
AU - Kim, Sinyoung
AU - Ahn, Hyeong Sik
AU - Choi, Young Sill
AU - Cho, Duck
AU - Lee, Dong Han
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
AB - Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.
KW - Adverse transfusion reactions
KW - Hemovigilance system
KW - Korea
KW - Trace back system
UR - http://www.scopus.com/inward/record.url?scp=84969268540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969268540&partnerID=8YFLogxK
U2 - 10.3343/alm.2016.36.4.335
DO - 10.3343/alm.2016.36.4.335
M3 - Article
C2 - 27139606
AN - SCOPUS:84969268540
VL - 36
SP - 335
EP - 341
JO - Annals of Laboratory Medicine
JF - Annals of Laboratory Medicine
SN - 2234-3806
IS - 4
ER -