Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014)

Jeong Ran Kwon, Eun Jeong Won, Hyun Jung Jo, Sae Rom Choi, Kyoungyul Lee, Sinyoung Kim, Hyeong Sik Ahn, Young Sill Choi, Duck Cho, Dong Han Lee

Research output: Contribution to journalArticle

Abstract

Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalAnnals of Laboratory Medicine
Volume36
Issue number4
DOIs
Publication statusPublished - 2016 Jul 1

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Korea
Viruses
Virus Diseases
Blood Safety
Disease control
Blood
Centers for Disease Control and Prevention (U.S.)
Infection
Hepatitis B virus
Hepacivirus
Deltaretrovirus Infections
Scrub Typhus
Human T-lymphotropic virus 1
Acute Lung Injury
Syphilis
Bacterial Infections
HIV Infections
Staphylococcus aureus
Transfusion Reaction
Sepsis

Keywords

  • Adverse transfusion reactions
  • Hemovigilance system
  • Korea
  • Trace back system

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014). / Kwon, Jeong Ran; Won, Eun Jeong; Jo, Hyun Jung; Choi, Sae Rom; Lee, Kyoungyul; Kim, Sinyoung; Ahn, Hyeong Sik; Choi, Young Sill; Cho, Duck; Lee, Dong Han.

In: Annals of Laboratory Medicine, Vol. 36, No. 4, 01.07.2016, p. 335-341.

Research output: Contribution to journalArticle

Kwon, Jeong Ran ; Won, Eun Jeong ; Jo, Hyun Jung ; Choi, Sae Rom ; Lee, Kyoungyul ; Kim, Sinyoung ; Ahn, Hyeong Sik ; Choi, Young Sill ; Cho, Duck ; Lee, Dong Han. / Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014). In: Annals of Laboratory Medicine. 2016 ; Vol. 36, No. 4. pp. 335-341.
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abstract = "Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8{\%}) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6{\%}), HIV infection (13, 6.5{\%}), syphilis (9, 4.5{\%}), malarial infection (4, 2.0{\%}), other bacterial infections (3, 1.5{\%}), HTLV infection (1, 0.5{\%}), and scrub typhus infection (1, 0.5{\%}), respectively. Of the 199 cases, 13 (6.5{\%}) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.",
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AU - Kwon, Jeong Ran

AU - Won, Eun Jeong

AU - Jo, Hyun Jung

AU - Choi, Sae Rom

AU - Lee, Kyoungyul

AU - Kim, Sinyoung

AU - Ahn, Hyeong Sik

AU - Choi, Young Sill

AU - Cho, Duck

AU - Lee, Dong Han

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AB - Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.

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