Serious adverse transfusion reactions reported in the national recipient-triggered trace back system in Korea (2006-2014)

Jeong Ran Kwon, Eun Jeong Won, Hyun Jung Jo, Sae Rom Choi, Kyoungyul Lee, Sinyoung Kim, Hyeong Sik Ahn, Young Sill Choi, Duck Cho, Dong Han Lee

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Adverse transfusion reactions (ATRs) are clinically relevant to patients with significant morbidity and mortality. This study aimed to review the cases of ATR reported in the recipient-triggered trace back system for a recent nine-year period in Korea. Methods: Nine-year data obtained from 2006 to 2014 by the trace back system at the Division of Human Blood Safety Surveillance of the Korean Centers for Disease Control (KCDC) were reviewed. The suspected cases were assessed according to six categories: (i) related to, (ii) probably related to, (iii) probably not related to, (iv) not related to transfusion, (v) unable to investigate, and (vi) under investigation. Results: Since 2006, 199 suspected serious ATRs were reported in hospitals and medical institutions in Korea, and these ATRs were reassessed by the division of Human Blood Safety Surveillance of the KCDC. Among the reported 193 cases as transfusion related infections, hepatitis C virus (HCV) infection (135, 67.8%) was reported most frequently, followed by hepatitis B virus (HBV) infection (27, 13.6%), HIV infection (13, 6.5%), syphilis (9, 4.5%), malarial infection (4, 2.0%), other bacterial infections (3, 1.5%), HTLV infection (1, 0.5%), and scrub typhus infection (1, 0.5%), respectively. Of the 199 cases, 13 (6.5%) cases were confirmed as transfusion-related (3 HCV infections, 3 malarial infections, 1 HBV infection, 2 Staphylococcus aureus sepsis, 3 transfusion-related acute lung injuries, and 1 hemolytic transfusion reaction). Conclusions: This is the first nationwide data regarding serious ATRs in Korea and could contribute to the implementation of an effective hemovigilance system.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalAnnals of laboratory medicine
Issue number4
Publication statusPublished - 2016 Jul


  • Adverse transfusion reactions
  • Hemovigilance system
  • Korea
  • Trace back system

ASJC Scopus subject areas

  • Medicine(all)


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